CCR1

CCR1, also known as C-C chemokine receptor type 1, is a protein with an alternative name of CMKBR1. It belongs to the G - protein - coupled receptor family. CCR1 binds to multiple chemokines, initiating signaling cascades upon ligand binding. This receptor is involved in the regulation of immune cell migration and activation. The signaling pathway related to CCR1 mainly includes the activation of downstream kinases through the G - protein - mediated mechanism.
CCR1 has been implicated in various diseases, such as multiple sclerosis, rheumatoid arthritis, and some types of cancer. In drug development, efforts are underway to design specific CCR1 antagonists to block its function. These antagonists are expected to provide novel therapeutic options for CCR1 - associated diseases.

Validated Data

CSB-MP004839HU is detected by Mouse anti-6*His monoclonal antibody.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CCR1 at 10 μg/ml can bind Anti-CCR1 recombinant antibody(CSB-RA004839MA1HU). The EC₅₀ is 9.690-10.94 ng/mL.The VLPs (CSB-MP3838) is negative control.

The purity of VLPs was greater than 90% as determined by SEC-HPLC

Recombinant Human C-C chemokine receptor type 1 (CCR1), partial(CSB-EP004839HU1)

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CCR1 Antibody(CSB-PA004839LA01HU)

Validated Data

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA004839LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA004839LA01HU at dilution of 1:100

Immunofluorescent analysis of U251 cells using CSB-PA004839LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

The following CCR1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CCR1 Antibodies

CCR1 Proteins

CCR1 Antibodies

CCR1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA004839LA01HU	CCR1 Antibody	Human	ELISA, IHC, IF
CSB-RA004839MA1HU	CCR1 Recombinant Monoclonal Antibody	Human	ELISA, IHC

CCR1 Antibodies for Arabidopsis thaliana (Mouse-ear cress)

Code	Product Name	Species Reactivity	Application
CSB-PA879677XA01DOA	CCR1 Antibody	Arabidopsis thaliana	ELISA, WB (ensure identification of antigen)
CSB-PA108622XA01DOA	CCR1 Antibody	Arabidopsis thaliana	ELISA, WB (ensure identification of antigen)

CCR1 Antibodies for Oryza sativa subsp. japonica (Rice)

Code	Product Name	Species Reactivity	Application
CSB-PA561580XA01OFG	CCR1 Antibody	Oryza sativa subsp. japonica (Rice)	ELISA, WB (ensure identification of antigen)

CCR1 Antibodies for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Code	Product Name	Species Reactivity	Application
CSB-PA018378XA01SXV	ccr1 Antibody	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	ELISA, WB (ensure identification of antigen)

CCR1 Proteins

CCR1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Code	Product Name	Source
CSB-YP650508MOV CSB-EP650508MOV CSB-BP650508MOV CSB-MP650508MOV CSB-EP650508MOV-B	Recombinant Macaca fascicularis C-C chemokine receptor type 1 (CCR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCR1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF004839HU	Recombinant Human C-C chemokine receptor type 1 (CCR1)	in vitro E.coli expression system
CSB-YP004839HU1 CSB-EP004839HU1 CSB-BP004839HU1 CSB-MP004839HU1 CSB-EP004839HU1-B	Recombinant Human C-C chemokine receptor type 1 (CCR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP004839HU1	Recombinant Human C-C chemokine receptor type 1 (CCR1), partial	E.coli
CSB-MP004839HU	Recombinant Human C-C chemokine receptor type 1 (CCR1)-VLPs (Active)	Mammalian cell

CCR1 Proteins for Arabidopsis thaliana (Mouse-ear cress)

Code	Product Name	Source
CSB-YP879677DOA CSB-EP879677DOA CSB-BP879677DOA CSB-MP879677DOA CSB-EP879677DOA-B	Recombinant Arabidopsis thaliana Serine/threonine-protein kinase-like protein CCR1 (CCR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCR1 Proteins for Macaca mulatta (Rhesus macaque)

Code	Product Name	Source
CSB-CF004839MOW	Recombinant Macaca mulatta (Rhesus macaque) C-C chemokine receptor type 1 (CCR1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP004839MOW1 CSB-EP004839MOW1 CSB-BP004839MOW1 CSB-MP004839MOW1 CSB-EP004839MOW1-B	Recombinant Macaca mulatta (Rhesus macaque) C-C chemokine receptor type 1 (CCR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCR1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Code	Product Name	Source
CSB-CF018378SXV	Recombinant Schizosaccharomyces pombe NADPH--cytochrome P450 reductase (ccr1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP018378SXV1 CSB-EP018378SXV1 CSB-BP018378SXV1 CSB-MP018378SXV1 CSB-EP018378SXV1-B	Recombinant Schizosaccharomyces pombe NADPH--cytochrome P450 reductase (ccr1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCR1 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF004839MO	Recombinant Mouse C-C chemokine receptor type 1 (Ccr1)	in vitro E.coli expression system
CSB-YP004839MO1 CSB-EP004839MO1 CSB-BP004839MO1 CSB-MP004839MO1 CSB-EP004839MO1-B	Recombinant Mouse C-C chemokine receptor type 1 (Ccr1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-MP004839MO	Recombinant Mouse C-C chemokine receptor type 1 (Ccr1)-VLPs	Mammalian cell

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CCR1

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