BRCA1

BRCA1, breast cancer susceptibility gene 1. also known as FANCS, PSCP, it is encoded by the human BRCA1 gene, which is located at position q21 on chromosome 17.
BRCA1 is a nucleophosmin that functions as a tumor suppressor and is involved in a variety of cellular processes, including transcription, repair of DNA double-strand breaks, and recombination. The mechanism of action of BRCA1 involves interaction with a multiple proteins to form the BRCA1-associated genome-monitoring complex (BASC), which is involved in DNA damage repair and cell cycle regulation. The BRCA1-BARD1 heterodimer exhibits E3Ub ligase activity, which is involved in DNA end resection and DNA protection.
BRCA1 is essential for the maintenance of genome stability, and mutations in it can lead to hereditary breast and ovarian cancers , affecting approximately 40% of hereditary breast cancers and more than 80% of hereditary breast and ovarian cancers.