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Recombinant Dog Breast cancer type 1 susceptibility protein homolog (BRCA1), partial

Recombinant Dog Breast cancer type 1 susceptibility protein homolog (BRCA1), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

BRCA1

Purity

>85% (SDS-PAGE)

Target Names

BRCA1

Uniprot NO.

Q95153

Alternative Names

BRCA1Breast cancer type 1 susceptibility protein homolog; EC 2.3.2.27; RING-type E3 ubiquitin transferase BRCA1

Species

Canis lupus familiaris (Dog) (Canis familiaris)

Source

Yeast

Expression Region

1-1878

Target Protein Sequence

MDLSADRVEE VQNVLNAMQK ILECPICLEL IKEPVSTKCD HIFCKFCMLK LLNQRKGPSQ CPLCKNDITK RSLQESTRFS QLVEELLKII HAFELDTGLQ FADSYNFSKK ENNSPEHLKE EVSIIQSMGY RNRAKRLRQS EPENPTLETS LSVQLSNLGI VRSLRTKQQI QPQNKSVYIE LGSDSSEDTV NKASSCSVGD DELEITSQGA RAEASLNPAK KAACEFSGDI TNIEHHQSSN KDLTTTEKHA TKKHPEKYQG ISVSNLHVEP CGTNTHASSL QHENSSLLLT KHRMNVEKAE ICNNSKQPGL ARSQQSRWAE SKETCNDRQI PSTEKKVVVN ADLLCGRKEL NKQKPPHSDS PRDSQDVPWI TLNSSIRKVN EWFSRSDEIL TSDDSHDRGS ELNTEVGGAV EVPNEVGEYS GSSEKIDLMA SDPQDAFICE SERVHTKPVG GNIEDKIFGK TYRRKASLPK VSHTTEVLTI GACAIEPQTM QTHPFMNKAE HKRRTTSSLH PEDFIKKVEL GIVPKTPEKL IEGINQIKRD GHVINITNNG PENETEGDYV QKEKNANPTE SLEKESAFRT KTEPMSSRIS NMELELNSSS SKAPKKNRLR RKSSARHTCA LEFVVNRNLN PPDHSELQIE SCSSSEEMKK QHLDQVPVRH NKTLQLMQDK EPAGRAKKSS KPGEQINKRL ASHAFPELTL TNVSGFFANY SSSSKPQECI NPGLRREEIE ESRRMTQVSD STRDPKELVL SGGRGLQTER SVESTSISLV LDTDYGTQDS ISLLEADTLR KAKTVSNQQA NLCATIENPK EPIHGCSKDT RNDTEGFVVP LTCKDNHTQE TSIEMEESEL DTQCLRNMFK VSKRQSFALF SYPRDPEEDC VTVCPRSGAF GKQGPKVTLE CGQKEESQGK KESEIRHVQA VHTNAGFSAV SQKAKKPGDF AKCSIKGVSR LCLSSQFKGK ETELLIANYH GISQNPYHIP PLSPIRSCVK TLCQENLSEE KFEQHSMSPE RAVGNERVIQ STVSTISQNN IRECASKEVG SSSVNEVVSS TNEVGSSVNE VGSSGENIQA ELGRNRGPKL NAMLRLGLMQ PEVCKQSLSL SNCKHPEMKW QGQSEGAVLS VSADFSPCLI SDNPEQPMGS SRSSQVCSET PDDLLNGDKI KGKVSFAESD IKEKSAVFSK SVQSGEFSRS PSPSDHTRLA QGYQRGTKKL ESSEENMSSE EEELPCFQHL IFGKVTNMPS QSTSHNAVAA EGLSNKTEEN LDSLKNSLSD ISNQVPSAKA SQEHHLSEEA RCSGSLFSSQ CSALEDLTVN TNTQDPFSMF DPTSKQVRHQ SENLDVLNDK ELVSDDDDER EPGLEEDSPQ EEQSVDSDLG EVASGYESET SLSEDCSRLS SQSDILTTQQ RDTMQDNLIK LQQEMAELEA VLEQHESQPS NSSPSLIADS CSPEDLLNPE QNASERVLTS EKSSDSPISQ NPESLSTDKF QVFLDSSTSK NGEPGMIRSS PSQSRLLDTR WYVHSCPRSL QDTNCPSQKE LTKVVSMEEQ QPTESEARDL MEQSYLSRPD LEGAPYLESG ISLFSDDPES DPSSHRASEL AHVSSMPTST SALKLPQFQV EESAKSTAAV HIASTAGYNK SEDSVGIEKP EVISSTRGVN KRISMVASGL TPKEFMLVHK FARKHHISLT NLISEETTHV IMKTDAEFVC ERTLKYFLGI AGGKWVVSYF WVTQSIKERK ILDEHDFEVR GDVVNGRNHQ GPKRARESQD RESQDRKIFR GLEICCYGPF TNMPTDQLEW MVHLCGASVV KEPSLFTLSK GTHPVVVVQP DAWTEDSGFH AIGQMCEAPV VTREWVLDSV ALYQCQELDT YLIPQIPRTA ADSSQPCV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator.

Gene References into Functions

Three previously unreported single-nucleotide polymorphisms in BRCA1 in canine mammary tumors are reported. PMID:26156012
46.7% of the malignant mammary tumors were found with a deletion of one cytosine in the promoter region. mRNA expression of BRCA1 was significantly reduced in benign and malignant mammary tumors. PMID:26679809
one SNP in exon 9 of BRCA1 and one SNP in exon 24 of BRCA2 were found to be significantly associated with canine mammary tumours PMID:24122022
The expression of multiple splice variants of BRCA1 in mammary gland tumors of dogs is reported. PMID:17611353
this study indicates that BRCA1 and BRCA2 contribute to the risk of canine mammary tumors in English springer spaniels PMID:19887619
The amino terminal RING finger motif and the granin consensus sequence are conserved between human, canine, and murine BRCA1 genes. PMID:8872468