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Recombinant Bovine Breast cancer type 1 susceptibility protein homolog (BRCA1), partial

Recombinant Bovine Breast cancer type 1 susceptibility protein homolog (BRCA1), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

BRCA1

Purity

>85% (SDS-PAGE)

Target Names

BRCA1

Uniprot NO.

Q864U1

Alternative Names

BRCA1; Breast cancer type 1 susceptibility protein homolog; EC 2.3.2.27; RING-type E3 ubiquitin transferase BRCA1

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

1-1849

Target Protein Sequence

MDLSADHVEE VQNVLNAMQK ILECPICLEL IKEPVSTKCD HIFCKFCMLK LLNQKKGPSQ CPLCKNDITK RSLQESTRFS QLVEELLKII HAFELDTGLQ FANSYNFSRK EDNSPEHLKE EVSIIQSMGY RNRAKRLWQS EPENPTLQET SLTVELSNLG IVRSLRTKQQ TQSQNKSVYI ELGSDSSEDT VNKASYFSVG DHELLEITPQ GAKAKTNLNP AEKAACEFSE KDITNTEHHQ LSIKDLITTQ KHATETHPEK YQGISVSDFH VEPCGTDTHA SSLQHENSSL LLTENRLNVE KAEFCNKSKQ PVLVKSQQSR WAESKGTCKD RQIPSTEKKI VLNTDPLYRR KELRKQKPAC PDSPGDSQDV PWVTLNNSIQ KVNDWFSRSD EILTSDDSCD GGSESNNEVA GAVEIPNKVD GYSGSSEKIN LMASDPHGTL IHERVHSKPV ESNIEDKIFG KTYRRKSSLP NFSHIAEDLI LGAFTVEPQI TQEQPLTNKL KCKRRGTSGL QPEDFIKKVD LTIVPKTPEK MTEGTDQTEQ KCHGMNITSD GHENKTKRDY VQKEQNANPA ESLEKESVFR TEAEPISISI SNMELELNIH RSKAPKNRLK RKSSTRKIPE LELVVSRNPS LPNHTELPID SSSSNEEMKK KHSSQMPVRQ SQKLQLIGDK ELTAGAKNNK TYEQINKRLA SDAFPELKLT NTPGYFTNCS SKPEEFVHPS LQREENLGTI QVSNSTKDPK DLILREGKAL QIERSVESTN ISLVPDTDYS TQDSISLLEA KTPEKAKTAP NPCVSLCTAT KNLKELIHRD FKDTKNNTEG FQDLLGHDIN YVIQETSREM EDSELDTQYL QNTFKASKRQ TFALFSNPGN PQKECATVFA HSGSLRDQSP RDPLKCRQKE DSQGKSESKS QHVQAICTTV HFPVADQQDR TPGDDAKCSA KEVTRVCQSS QLRGHKTELV FANKQGVSEK PNLIPSLSPI KSSVKTICKK SPSEKFEEPV TSPEKTLGSE SIIQSAVSTI SQNNIQESTF KEVSSNSVNE VGSSTNEVGS SVNEVGSSGE NIQAEPGRNR EPKLRALLGL GLTQPEVYKQ SLPVSNCHHP EIKRQGENED MPQAVKADFS PCLISDNLEQ PTGSRHASQV CSETPDNLLN DDEIKENSHF AESDIKERSA VFSESVQKGE FRGSPGPFTH THLAQGHQRG AGKLESEETV SSEDEELPCF QQLLFGKVTS TLSPSTGCNT VATEGLSKET EGNLESLKSG LNDCSGQVTS AKVSQEHHLN EEARCSGSLF SSQCSAMEDL TTNTNTQDPF LMFERPSKQV YQSESEEVLS DKELVSDDEE RETGLEEDSC QEEQSVDSDL GEAVSDHVSE TSLSEDGVGL SSQSDILTTQ QRDTMQDNLL KLQQEMAELE AVLERHGSQP SHSSASLTAD SRGPEHLLNL EQDTSERAIL TSEKSRDYSR SQNPESLSAD KFPVSLDSST NKNKEPGMER SSASKFQLSY NRWYMHSSRS LQDRNCPSQK EPINVADMEE QQLAKREAQD LMGSFLPRQD QEGTPYLKSG ISLFSHEPES DPSEDRAAEP AHVHSMPPSA SALKLSQFRV EESTKNPAAA HIANTTRCNL REESMSKEKP EVISSTERSK KRLSMVASGL TPKELMLVQK FARKHHVTLT NLITEETTHV IMKTDPEFVC ERTLKYFLGI AGGKWVVSYF WVTQSIKEGK MLDEHDFEVR GDVVNGRNHQ GPKRARESRD KKIFKGLEIC CYGPFTNMPT DQLEWMVQLC GASVVKEPSS FTPDQGTHPV VVVQPDAWTE DAGFHVIGQM CEAPVVTREW VLDSVALYQC QELDTYLVP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator.

Gene References into Functions

Investigation on BRCA1 SNPs and its effects on mastitis in Chinese commercial cattle. PMID:22583824
The gene-specific SNP marker analysis showed a significant association of BRCA1 C28300A with milk somatic cell scores. PMID:22327776
In general, OC use, childbearing and breastfeeding do not differ between BRCA1/2 carriers and non-carriers with ovarian cancer. However, the effects of tubal ligation may differ between BRCA1 carriers and non-carriers. PMID:12946038
Bovine BRCA1 was phosphorylated and nuclear speckling was enhanced in response to DNA-damaging agents.These results provide evidence that phosphorylation and nuclear relocalization are highly conserved features of the BRCA1 response to genotoxic stress. PMID:12955082