ACHE, recognized for its role as acetylcholinesterase, is instrumental in the realm of nerve impulse transmission. Predominantly sourced from living organisms, ACHE is particularly influential in cholinergic synaptic clefts. It functions by breaking down acetylcholine (ACh), thus quenching the neurotransmitter's excitatory effect on the postsynaptic membrane and ensuring seamless neural signal transmission. ACHE also plays a part in cellular growth and maturation, fostering neuronal development and nerve regeneration. Its connection to diseases such as Alzheimer's and liver cancer is well-documented; in Alzheimer's, ACHE inhibition leads to ACh accumulation, alleviating cognitive symptoms. In liver cancer, diminished ACHE expression is linked to cancer cell proliferation, hinting at its potential as a liver cancer prognostic indicator.
Popular
Product:
ACHE Antibody(CSB-PA5619A0Rb)
Validated Data
IHC image of CSB-PA5619A0Rb diluted at 1:300 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of MCF-7 cells with CSB-PA5619A0Rb at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
The following ACHE
reagents supplied by CUSABIO are manufactured under a
strict quality control system. Multiple applications
have been validated and solid technical support is
offered.
ACHE Proteins
ACHE Proteins for Gallus gallus (Chicken)
ACHE Proteins for Electrophorus electricus (Electric eel) (Gymnotus electricus)
ACHE Proteins for Homo sapiens (Human)
ACHE Proteins for Bos taurus (Bovine)
ACHE Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
ACHE Proteins for Naja oxiana (Central Asian cobra) (Oxus cobra)
ACHE Proteins for Felis catus (Cat) (Felis silvestris catus)
ACHE Proteins for Myxine glutinosa (Atlantic hagfish)
ACHE Proteins for Oryctolagus cuniculus (Rabbit)
ACHE Proteins for Rattus norvegicus (Rat)
ACHE Proteins for Mus musculus (Mouse)
ACHE Proteins for Torpedo marmorata (Marbled electric ray)
ACHE Proteins for Bungarus fasciatus (Banded krait) (Pseudoboa fasciata)
ACHE Proteins for Torpedo californica (Pacific electric ray)
