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MUC17 (US8546546B2 Biosimilar) Recombinant Monoclonal Antibody

MUC17 (US8546546B2 Biosimilar) Recombinant Monoclonal Antibody

Code: CSB-RA727848MB1HU

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Size:

100ug

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US$199

Quantity:

Species Reactivity: Human

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Product Details
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Target Background

Product Details

Uniprot NO.

Q685J3

Target Names

MUC17

Alternative Names

Mucin-17, MUC-17, Small intestinal mucin-3；MUC-3, MUC17, MUC3

Species Reactivity

Human

Immunogen

Recombinant Human MUC17 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

0.01M PBS，pH7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Notes

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Lead Time

In stock
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Datasheet & COA

Antibody FAQs

Description

This recombinant monoclonal antibody is developed as a research-grade biosimilar to the reference antibody described in US8546546B2, specifically targeting MUC17 (Mucin 17). MUC17 is a membrane-bound mucin glycoprotein predominantly expressed in the gastrointestinal tract, where it plays crucial roles in maintaining the protective mucus barrier, regulating epithelial cell differentiation, and modulating cell signaling pathways. This mucin has emerged as a significant biomarker in gastrointestinal malignancies, particularly gastric and pancreatic cancers, where its aberrant expression patterns correlate with tumor progression, metastasis, and patient prognosis. MUC17 overexpression has also been implicated in colorectal cancer development and chemoresistance mechanisms.

The reference antibody patent US8546546B2 describes antibodies with specific binding properties to MUC17, providing a foundation for investigating this target in oncology research. This biosimilar antibody serves as a valuable research tool for studying MUC17 expression patterns, exploring its functional roles in gastrointestinal physiology and pathology, and evaluating its potential as a therapeutic target or diagnostic marker in cancer research applications.

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Target Background

Function(From Uniprot)

Probably plays a role in maintaining homeostasis on mucosal surfaces.

Gene References into Functions

MUC17 polymorphisms are involved in endometriosis development and the associated infertility in the Taiwanese population. PMID:26285705
Carbachol stimulated enterocyte MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment. PMID:23784542
The HIF1alpha-mediated hypoxic signal pathway contributes to MUC17 expression, and DNA methylation of hypoxia responsive element could be a determinant of the hypoxic inducibility of MUC17 in pancreatic cancer cells. PMID:22970168
Both native and exogenous MUC17 play a role in attachment and invasion of enteroinvasive E. coli in colonic cell lines and in maintaining epithelial barrier function. PMID:21393431
Hypomethylation status in the MUC17 promoter could be a novel epigenetic marker for the diagnosis of Pancreatic ductal adenocarcinomas. PMID:20926598
Results indicate that the potential protective effects of this membrane-bound mucin are primarily or secondarily diminished in inflammatory and neoplastic conditions. PMID:20702471
augments intestinal cell restitution and enhances healing of experimental colitis in mice PMID:20211273
The authors demonstrate that apically atypical enteropathogenic Escherichia coli infection is followed by increased production of secreted MUC2 and MUC5AC mucins and membrane-bound MUC3 and MUC4 mucins. PMID:20065027
sequence homology & chromosome mapping PMID:11855812
surface localization of the smaller subunit of MUC17 is dependent on its N-glycosylation status PMID:12888891
The MUC17 sequence has been extended toward its 5'-extremity to complete the sequence and localize the promoter and regulatory elements. PMID:16737958
Pdzk1 plays a specific role in stabilizing Muc17 in the apical membrane of small intestinal enterocytes. PMID:17990980

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Subcellular Location

[Isoform 1]: Cell membrane; Single-pass membrane protein.; [Isoform 2]: Secreted. Cell membrane.

Tissue Specificity

Expressed almost exclusively in the intestine. Expression is especially high in both the duodenum and transverse colon. Expressed in mature absorptive cells of the small intestinal villi. No expression is detected in goblet cells. Highly expressed in panc

Database Links

HGNC: 16800

UNIGENE: Hs.271819

KEGG: hsa:140453

STRING: 9606.ENSP00000302716

OMIM: 608424

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