MUC17 Recombinant Monoclonal Antibody

CSB-RA727848MA1HU

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Size:

50μl100μl

US$210

Quantity:

Species Reactivity: Human

Application: ELISA

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Product Details
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Target Background

Product Details

Uniprot NO.

Q685J3

Alternative Names

Mucin-17, MUC-17, Small intestinal mucin-3 (MUC-3), MUC17, MUC3

Species Reactivity

Human

Immunogen

Recombinant Human MUC17 protein

Conjugate

Non-conjugated

Clonality

Monoclonal

Isotype

Human IgG

Clone No.

8D12

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Scope Application

ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Protocols

ELISA Protocol

Datasheet & COA

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MUC17 Recombinant Monoclonal Antibody

Description

Customer Reviews and Q&A

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Target Background

Function

Probably plays a role in maintaining homeostasis on mucosal surfaces.

Gene References into Functions

MUC17 polymorphisms are involved in endometriosis development and the associated infertility in the Taiwanese population. PMID:26285705
Carbachol stimulated enterocyte MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment. PMID:23784542
The HIF1alpha-mediated hypoxic signal pathway contributes to MUC17 expression, and DNA methylation of hypoxia responsive element could be a determinant of the hypoxic inducibility of MUC17 in pancreatic cancer cells. PMID:22970168
Both native and exogenous MUC17 play a role in attachment and invasion of enteroinvasive E. coli in colonic cell lines and in maintaining epithelial barrier function. PMID:21393431
Hypomethylation status in the MUC17 promoter could be a novel epigenetic marker for the diagnosis of Pancreatic ductal adenocarcinomas. PMID:20926598
Results indicate that the potential protective effects of this membrane-bound mucin are primarily or secondarily diminished in inflammatory and neoplastic conditions. PMID:20702471
augments intestinal cell restitution and enhances healing of experimental colitis in mice PMID:20211273
The authors demonstrate that apically atypical enteropathogenic Escherichia coli infection is followed by increased production of secreted MUC2 and MUC5AC mucins and membrane-bound MUC3 and MUC4 mucins. PMID:20065027
sequence homology & chromosome mapping PMID:11855812
surface localization of the smaller subunit of MUC17 is dependent on its N-glycosylation status PMID:12888891
The MUC17 sequence has been extended toward its 5'-extremity to complete the sequence and localize the promoter and regulatory elements. PMID:16737958
Pdzk1 plays a specific role in stabilizing Muc17 in the apical membrane of small intestinal enterocytes. PMID:17990980

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Subcellular Location

[Isoform 1]: Cell membrane; Single-pass membrane protein.; [Isoform 2]: Secreted. Cell membrane.

Tissue Specificity

Expressed almost exclusively in the intestine. Expression is especially high in both the duodenum and transverse colon. Expressed in mature absorptive cells of the small intestinal villi. No expression is detected in goblet cells. Highly expressed in panc

Database Links

HGNC: 16800

UNIGENE: Hs.271819

KEGG: hsa:140453

STRING: 9606.ENSP00000302716

OMIM: 608424

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