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IL13RA1 (eblasakimab Biosimilar) Recombinant Monoclonal Antibody

IL13RA1 (eblasakimab Biosimilar) Recombinant Monoclonal Antibody

Code: CSB-RA011591MB1HU

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Size:

100ug

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US$199

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Species Reactivity: Human

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Product Details
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Target Background

Product Details

Uniprot NO.

P78552

Alternative Names

bB128O4.2.1；interleukin 13 receptor; alpha 1 antibody; Cancer/testis antigen 19 antibody; CD213a1 antibody; CD213A1 Antigen antibody; CT 19 antibody; CT19 antibody; I13R1_HUMAN antibody; IL 13 receptor subunit alpha 1 antibody; IL 13R alpha 1 antibody; IL 13R subunit alpha 1 antibody; IL 13Ra antibody; IL 13RA1 antibody; IL-13 receptor subunit alpha-1 antibody; IL-13R subunit alpha-1 antibody; IL-13R-alpha-1 antibody; IL-13RA1 antibody; IL13 receptor alpha 1 chain antibody; IL13R antibody; IL13RA antibody; Il13ra1 antibody; Interleukin 13 receptor alpha 1 antibody; Interleukin 13 receptor alpha 1 chain antibody; interleukin 13 receptor subunit alpha 1 antibody; Interleukin-13 receptor subunit alpha-1 antibody; NR 4 antibody; NR4 antibody

Species Reactivity

Human

Immunogen

Recombinant Human IL13RA1 protein

Conjugate

Non-conjugated

Clonality

Monoclonal

Buffer

0.01M PBS，pH7.4

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Notes

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Lead Time

In stock
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Concentration

It differs from different batches. Please contact us to confirm it.

Usage

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Datasheet & COA

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Description

This recombinant monoclonal antibody is designed as a research-grade biosimilar to eblasakimab, targeting interleukin-13 receptor alpha 1 (IL13RA1). IL13RA1 serves as a receptor subunit for interleukin-13, a key cytokic involved in type 2 immune responses and allergic inflammation. This receptor mediates IL-13 signaling pathways that regulate IgE production, mucus secretion, and airway hyperresponsiveness. Dysregulated IL13RA1 expression and signaling are implicated in various pathological conditions, including asthma, atopic dermatitis, chronic obstructive pulmonary disease, and certain malignancies where it contributes to tumor progression and therapeutic resistance.

Eblasakimab represents a therapeutic antibody developed to modulate IL-13 signaling through IL13RA1 blockade, with clinical investigation in inflammatory and allergic disorders. This biosimilar antibody provides researchers with a valuable tool for investigating IL-13/IL13RA1 pathway mechanisms, exploring therapeutic intervention strategies, and studying receptor-mediated immune responses in preclinical models. It supports diverse research applications in immunology, respiratory disease, dermatology, and oncology.

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Target Background

Function(From Uniprot)

Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.

Gene References into Functions

High IL13RA1 expression is associated with Invasive breast Cancer. PMID:28634667
in humans and mice indicate, for the first time, a role of interleukin-13 receptor alpha1 in myocardial homeostasis and heart failure and suggests a new therapeutic target to treat heart disease. PMID:28528324
sIL13ralpha1 as a circulating human protein with an unexpected role in glucose metabolism. PMID:28874358
IL-13Ralpha1 has a protective role in bleomycin-induced pulmonary injury and repair. PMID:26153764
required for induction of the alternative macrophage activation pathway by IL-13 but not by IL-4 PMID:25766112
Results identified FAM120A in the IL13/IL13Ralpha2 signaling pathway as a key mediator of invasion and liver metastasis in colon cancer. PMID:25896327
miR-143 regulation of IL-13-induced inflammatory cytokine and mucus production in nasal epithelial cells from allergic rhinitis patients probably partly depends on inhibition of IL13Ralpha1. PMID:25529447
MiR-143 may be associated with allergic reaction in human mast cells via downregulation of IL13RA1. PMID:23965966
In humans, IL-13Ralpha1 lies within the PARK12 locus of susceptibility to Parkinson's disease and may have a role in the pathogenesis of this neurodegenerative disease. PMID:23169588
These results indicate that an inherited polymorphism of the IL-4R controls the ability of the human immune system to regulate the magnitude of IL-17 production PMID:21294892
The IL-13R A(1) +1398 A/G polymorphism does not contribute to asthma or allergic rhinitis susceptibility. PMID:21425907
IL-13Ralpha1 is expressed on human CD4(+) T(H)17 cells PMID:21236478
Mutation and functional analysis in human malignant glioma cells PMID:11939409
IL4RA and STAT6 are candidate genes for atopic disorders. 26 single-nucleotide polymorphisms (SNPs)and simple repeats are being reported spanning a total of 147kb in IL4RA and STAT6 genes of the Indian population PMID:12522691
Allele frequency of IL13RA1 polymorphism was not associated with rapid decline of lung function in smokers. PMID:12594065
Overexpression of IL-13Ralpha1 may play some role in pathogenesis of chronic stage of atopic dermatitis or psoriasis. PMID:14527737
Bronchial submucosal mast cell IL-13 receptor alpha 1 expression is higher in asthmatics than normal controls. PMID:16918506
IL-13Ralpha1 polymorphism was associated with higher total IgE in children with atopic asthma PMID:17006604
the IL13RA1 subunit gene -281T>G and 1365A>G polymorphisms do not contribute to asthma susceptibility or severity, although the IL13RA1 subunit gene locus might be involved in the control of immunoglobulin E production PMID:17392323
concomitant expression of IL-13Ralpha1 and IL-13Ralpha2 may be associated with the pathogenesis of idiopathic interstitial pneumonia. PMID:19654941

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Type I cytokine receptor family, Type 5 subfamily

Tissue Specificity

Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.

Database Links

HGNC: 5974

UNIGENE: Hs.496646

KEGG: hsa:3597

STRING: 9606.ENSP00000360730

OMIM: 300119

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