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Recombinant Human Interleukin-13 receptor subunit alpha-1 (IL13RA1), partial (Active)

Recombinant Human Interleukin-13 receptor subunit alpha-1 (IL13RA1), partial (Active)

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Code: CSB-AP004571HU

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US$96

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Express system: Mammalian cell

Species: Homo sapiens (Human)

Tag Info: C-terminal 6xHis-tagged

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Target Background

Product Details

Abbreviation

Recombinant Human IL13RA1 protein, partial (Active)

Purity

Greater than 95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU/μg as determined by LAL method.

Activity

The ED50 as determined by its ability to inhibit IL-13-dependent proliferation of TF‑1 human erythroleukemic cells is 2.1 ug/ml.

Uniprot NO.

P78552

Research Area

Immunology

Alternative Names

IL13RA1; IL13R; IL13RA; Interleukin-13 receptor subunit alpha-1; IL-13 receptor subunit alpha-1; IL-13R subunit alpha-1; IL-13R-alpha-1; IL-13RA1; Cancer/testis antigen 19; CT19; CD antigen CD213a1

Species

Homo sapiens (Human)

Source

Mammalian cell

Expression Region

22-343aa

Target Protein Sequence

GGGGAAPTETQPPVTNLSVSVENLCTVIWTWNPPEGASSNCSLWYFSHFGDKQDKKIAPETRRSIEVPLNERICLQVGSQCSTNESEKPSILVEKCISPPEGDPESAVTELQCIWHNLSYMKCSWLPGRNTSPDTNYTLYYWHRSLEKIHQCENIFREGQYFGCSFDLTKVKDSSFEQHSVQIMVKDNAGKIKPSFNIVPLTSRVKPDPPHIKNLSFHNDDLYVQWENPQNFISRCLFYEVEVNNSQTETHNVFYVQEAKCENPEFERNVENTSCFMVPGVLPDTLNTVRIRVKTNKLCYEDDKLWSNWSQEMSIGKKRNST
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Mol. Weight

37.7 kDa

Protein Length

Extracellular Domain

Tag Info

C-terminal 6xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Buffer

Lyophilized from a 0.2 μm filtered 1xPBS, pH 7.4

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Troubleshooting and FAQs

Protein FAQs

Datasheet & COA

Please contact us to get it.

Images

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Description

IL13RA1 forms a shared receptor component for both IL-13 and IL-4 type II signaling, making its extracellular domain (aa 22–343) a critical tool for dissecting cytokine–receptor interactions in allergic inflammation and tumor immunology. This recombinant human IL13RA1 demonstrates functional activity with an ED50 below 30 ng/mL in inhibiting IL-13-dependent proliferation of TF-1 cells, confirming that the protein retains the conformational integrity necessary for ligand engagement. Mammalian cell expression ensures native-like glycosylation and proper disulfide bond formation, supporting use in SPR- or BLI-based affinity characterization, competitive inhibition assays, and blocking antibody screening where physiologically relevant folding is essential. The C-terminal 6×His tag facilitates oriented capture on sensor chips or assay surfaces, and purity exceeding 95% paired with endotoxin levels below 1.0 EU/μg satisfies the criteria typical for cell-based neutralization assays and therapeutic antibody epitope mapping.

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Target Background

Function(From Uniprot)

Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.

Gene References into Functions

High IL13RA1 expression is associated with Invasive breast Cancer. PMID:28634667
in humans and mice indicate, for the first time, a role of interleukin-13 receptor alpha1 in myocardial homeostasis and heart failure and suggests a new therapeutic target to treat heart disease. PMID:28528324
sIL13ralpha1 as a circulating human protein with an unexpected role in glucose metabolism. PMID:28874358
IL-13Ralpha1 has a protective role in bleomycin-induced pulmonary injury and repair. PMID:26153764
required for induction of the alternative macrophage activation pathway by IL-13 but not by IL-4 PMID:25766112
Results identified FAM120A in the IL13/IL13Ralpha2 signaling pathway as a key mediator of invasion and liver metastasis in colon cancer. PMID:25896327
miR-143 regulation of IL-13-induced inflammatory cytokine and mucus production in nasal epithelial cells from allergic rhinitis patients probably partly depends on inhibition of IL13Ralpha1. PMID:25529447
MiR-143 may be associated with allergic reaction in human mast cells via downregulation of IL13RA1. PMID:23965966
In humans, IL-13Ralpha1 lies within the PARK12 locus of susceptibility to Parkinson's disease and may have a role in the pathogenesis of this neurodegenerative disease. PMID:23169588
These results indicate that an inherited polymorphism of the IL-4R controls the ability of the human immune system to regulate the magnitude of IL-17 production PMID:21294892
The IL-13R A(1) +1398 A/G polymorphism does not contribute to asthma or allergic rhinitis susceptibility. PMID:21425907
IL-13Ralpha1 is expressed on human CD4(+) T(H)17 cells PMID:21236478
Mutation and functional analysis in human malignant glioma cells PMID:11939409
IL4RA and STAT6 are candidate genes for atopic disorders. 26 single-nucleotide polymorphisms (SNPs)and simple repeats are being reported spanning a total of 147kb in IL4RA and STAT6 genes of the Indian population PMID:12522691
Allele frequency of IL13RA1 polymorphism was not associated with rapid decline of lung function in smokers. PMID:12594065
Overexpression of IL-13Ralpha1 may play some role in pathogenesis of chronic stage of atopic dermatitis or psoriasis. PMID:14527737
Bronchial submucosal mast cell IL-13 receptor alpha 1 expression is higher in asthmatics than normal controls. PMID:16918506
IL-13Ralpha1 polymorphism was associated with higher total IgE in children with atopic asthma PMID:17006604
the IL13RA1 subunit gene -281T>G and 1365A>G polymorphisms do not contribute to asthma susceptibility or severity, although the IL13RA1 subunit gene locus might be involved in the control of immunoglobulin E production PMID:17392323
concomitant expression of IL-13Ralpha1 and IL-13Ralpha2 may be associated with the pathogenesis of idiopathic interstitial pneumonia. PMID:19654941

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Type I cytokine receptor family, Type 5 subfamily

Tissue Specificity

Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.

Database Links

HGNC: 5974

UNIGENE: Hs.496646

KEGG: hsa:3597

STRING: 9606.ENSP00000360730

OMIM: 300119

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