CD93 Recombinant Monoclonal Antibody

Code: CSB-RA865099MA1HU

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Size:

50μl100μl

US$210

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Species Reactivity: Human, Macaca fascicularis

Application: ELISA, FC

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Target Background

Product Details

Uniprot NO.

Q9NPY3

Target Names

CD93

Alternative Names

C1q receptor 1 antibody; C1q/MBL/SPA receptor antibody; C1qR antibody; C1qR(p) antibody; C1qr1 antibody; C1QR1_HUMAN antibody; C1qRp antibody; CD93 antibody; CD93 antigen antibody; CD93 molecule antibody; CDw93 antibody; Complement component 1 q subcomponent receptor 1 antibody; Complement component C1q receptor antibody; dJ737E23.1 antibody; ECSM3 antibody; Matrix remodeling associated protein 4 antibody; Matrix remodelling associated 4 antibody; Matrix-remodeling-associated protein 4 antibody; MXRA4 antibody

Species Reactivity

Human, Macaca fascicularis

Immunogen

Recombinant Human CD93 protein

Conjugate

Non-conjugated

Clonality

Monoclonal

Isotype

hIgG1

Clone No.

15B9

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Scope Application

ELISA Protocol Flow Cytometry (FC) Protocol

Recommended Dilution

Application	Recommended Dilution
FC	1:20-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

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The Binding Activity of Macaca fascicularis CD93 with Anti-CD93 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis CD93 (CSB-MP4279MOV) at 2 μg/mL can bind Anti-CD93 recombinant antibody. The EC₅₀ is 0.1669-0.3513 ng/mL.
The Binding Activity of Human CD93 with Anti-CD93 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD93 (CSB-MP865099HU) at 2 μg/mL can bind Anti-CD93 recombinant antibody. The EC₅₀ is 0.6639-1.173 ng/mL.
Untransfected CHO-K1*10⁶cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

Description

CD93 is a transmembrane glycoprotein that plays multifaceted roles in immune regulation, vascular biology, and cellular adhesion. Originally identified as a receptor for complement component C1q, this protein has since emerged as a critical player in angiogenesis, endothelial cell migration, and phagocytosis of apoptotic cells. Its expression on hematopoietic stem cells, endothelial cells, and various immune cell populations makes CD93 a valuable marker for researchers investigating cardiovascular development, inflammatory responses, and stem cell biology.

This recombinant monoclonal antibody, clone 15B9, offers the reproducibility and consistency that demanding experimental workflows require. Because recombinant antibodies are produced from defined sequences rather than hybridoma supernatants, you can expect identical performance characteristics across lots, eliminating the variability that can compromise longitudinal studies or multi-site collaborations. The human IgG1 isotype and affinity-chromatography purification ensure high purity suitable for sensitive detection methods.

Validation studies demonstrate robust binding activity across species. Functional ELISA testing shows strong interaction with both human CD93, achieving an EC50 of 0.6639–1.173 ng/mL, and Macaca fascicularis CD93 with an EC50 of 0.1669–0.3513 ng/mL. This cross-species reactivity provides flexibility for researchers working with primate models in translational studies. Flow cytometry validation confirms the antibody's utility for cell surface detection, with recommended dilutions ranging from 1:20 to 1:200 depending on your specific experimental conditions.

Whether you are characterizing endothelial cell populations, investigating complement-mediated immune responses, or identifying hematopoietic progenitors, this antibody delivers the specificity and batch-to-batch reliability essential for meaningful results in cardiovascular, immunology, and stem cell research.

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Target Background

Function(From Uniprot)

Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.

Gene References into Functions

Report increased CD93 expression in patients with chronic plaque psoriasis and propose the C allele of rs2749817 as a new risk allele for psoriasis. PMID:28421233
Results show that CD93 and MMRN2 are co-expressed in the blood vessels of various tumors and their interaction modulates the angiogenic process. PMID:28912033
These findings identify novel protein interactions involving CLEC14A, CD93 and CD248 with MMRN2 as targetable components of vessel formation PMID:28671670
CD93 and Other Plasma Cell Survival Factor Genes Associated with Measles-Specific Antibody Response after Vaccination PMID:27529750
Soluble expression of disulfide-bonded C-type lectin like domain of human CD93 in the cytoplasm of Escherichia coli. The recombinant protein could alter LPS pro-inflammatory activity on THP1 cells. PMID:27742562
Vascular CD93 expression is elevated in nasopharyngeal carcinoma and is correlated with T classification, N classification, distant metastasis, clinical stage and poor prognosis (all P < 0.05). In addition, overexpression of CD93 promoted angiogenesis in vitro. PMID:27255994
both transmembrane and soluble CD93 are overexpressed in patients with neovascular Age-Related Macular Degeneration. PMID:27859225
Elevated serum sCD93 levels reflected exacerbated status of allergic diseases, including CSU [chronic spontaneous urticaria ], AR[allergic rhinitis], and asthma. ICS [inhaled corticosteroid] use significantly diminished serum sCD93 levels in steroid-naive patients with BA[Bronchial asthma]. This result may suggest sCD93 in serum as a therapeutic marker for allergic inflammation. PMID:28332366
Data show that CD93 antigen proved to be phosphorylated on tyrosine 628 and 644 following cell adhesion on laminin through dystroglycan. PMID:26848865
CD93 expression identifies a predominantly cycling, non-quiescent leukemia-initiating cell population in MLL-rearranged AML, providing opportunities for selective targeting and eradication of LSCs. PMID:26387756
The T/T genotype of SNP rs2749817 of CD93 is associated with disseminated cancer. PMID:26008729
CD93 is a key regulator of glioma angiogenesis and vascular function, acting via cytoskeletal rearrangements required for cell-cell and cell-matrix adhesion. PMID:26363010
These data support a mechanism whereby gC1qR plays an important role in HPV-16 E2-induced human cervical squamous carcinoma cell apoptosis via a mitochondria-dependent pathway. PMID:25288439
The data indicate that gC1qR inhibits viability, migration and proliferation of cervical squamous cells carcinoma via the p38 MAPK signalling pathway. PMID:23052251
Antibody-dependent enhancement of parvovirus B19 involves an alternative mechanism mediated by the heat-sensitive complement factor C1q and its receptor, CD93. PMID:24807719
Expression of CD93 on the lymphocyte population of peripheral blood cells from infants at 1 month after birth was also significantly decreased, compared with that for neonatal umbilical cord blood. PMID:24033555
HPV 16 E2 induces apoptosis by silencing the gC1qR gene or inhibiting p38 MAPK/JNK signalling in cervical squamous cell carcinoma PMID:23651874
These data support a mechanism whereby gC1qR induces apoptosis through the mitochondrial and p53-dependent pathways in cervical squamous cell carcinoma. PMID:23268996
soluble EGF-like domain containing CD93 protein is a novel angiogenic factor acting on the endothelium PMID:23272129
[review] Following a comprehensive summary of CD93 expression patterns, this review focuses on recent findings that address the putative function of CD93 in inflammation and innate immunity. PMID:22206251
Data show that Pic, a class 2 SPATE protein produced by Shigella flexneri 2a targets a broad range of human leukocyte glycoproteins including CD43, CD44, CD45, CD93, CD162 and the surface-attached chemokine fractalkine. PMID:21768350
Results suggest that the plasma concentration of soluble CD93 is a potential novel biomarker for Coronary Artery Disease (CAD), including MI. PMID:21332844
expression on naive T lymphocytes (CD4(+)CD45RA (+) cells) in human neonatal umbilical cord blood PMID:20512406
both B1 receptor and gC1q receptor are involved in the vascular leakage induced by hereditary and acquired angioedema plasma. PMID:19796797
To clarify the cellular and molecular properties of C1qRp it has been demonstrated that C1q does not show enhanced binding to C1qRp-transfected cells, is not a receptor for C1q, and is identical to CD93 with functions relevant to intercellular adhesion. PMID:11994479
C1qRp defines a new human stem cell population with hematopoietic and hepatic potential PMID:12140365
O-glycosylation is important in the stable cell surface expression of C1qRP/CD93 PMID:12891708
Taken together, these findings indicate that the expression of the CD93 molecule identified by CD93 mAb (mNI-11) is dramatically decreased on U937 cells with apoptotic properties PMID:18094537
RNAi-mediated suppression of gC1qR/p32 markedly reduced HTNV binding and infection in human lung epithelial A549 cells PMID:18834607

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Tissue Specificity

Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. Not expressed in cells of lymphoid origin.

Database Links

HGNC: 15855

UNIGENE: Hs.97199

KEGG: hsa:22918

STRING: 9606.ENSP00000246006

OMIM: 120577

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