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Recombinant Human FUN14 domain-containing protein 1 (FUNDC1), partial, Biotinylated

Recombinant Human FUN14 domain-containing protein 1 (FUNDC1), partial, Biotinylated

Code: CSB-EP816886HU-B

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Size:

20ug100ug1mg

US$308

Quantity:

Express system: E.coli

Species: Homo sapiens (Human)

Tag Info: N-terminal MBP-tagged and C-terminal 6xHis-Avi-tagged

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Target Background

Product Details

Abbreviation

Recombinant Human FUNDC1 protein, partial, Biotinylated

Purity

≥95% as determined by SDS-PAGE.

Target Names

FUNDC1

Uniprot NO.

Q8IVP5

Research Area

Signal Transduction

Species

Homo sapiens (Human)

Source

E.coli

Expression Region

96-133aa

Mol. Weight

52.2 kDa

Protein Length

Partial

Tag Info

N-terminal MBP-tagged and C-terminal 6xHis-Avi-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.

Lead Time

Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

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Target Background

Function(From Uniprot)

Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.

Gene References into Functions

Our data suggested that FUNDC1 can be used as a prognostic biomarker in patients with cervical cancer, and may be a new therapeutic target to improve the antitumor effects of chemoradiotherapy. PMID:28719148
phosphorylation of Tyr18 of FUNDC1 serves as a molecular switch for mitophagy. PMID:27653272
FUNDC1 integrates mitochondrial fission and mitophagy at the interface of the endoplasmic reticulum-mitochondrial contact site by working in concert with DRP1 and calnexin under hypoxic conditions in mammalian cells. PMID:27145933
FUNDC1 regulates both mitochondrial fission or fusion and mitophagy. PMID:27050458
The BCL2L1-PGAM5-FUNDC1 axis is critical for receptor-mediated mitophagy. PMID:25126723
FUNDC1 regulates ULK1 recruitment to damaged mitochondria, where FUNDC1 phosphorylation by ULK1 is crucial for mitophagy. PMID:24671035
Data show that Knockdown of endogenous FUNDC1 significantly prevented hypoxia-induced mitophagy, which could be reversed by the expression of wild-type FUNDC1. PMID:22267086