Recombinant Mouse Tumor necrosis factor receptor superfamily member 17 (Tnfrsf17), partial

1. high affinity antibody blocks the binding of the native ligands APRIL and BAFF to BCMA. This finding is rationalized by the high resolution crystal structure of the Fab fragment in complex with the extracellular domain of BCMA PMID:25953704
2. Elimination of B lymphocyte stimulator receptor 3 (BR-3) and BCMA inhibits the development of SLE in NZM mice. PMID:25989238
3. we have identified a novel role for BCMA to control excess BAFF production in murine lupus through restraining the accumulation of BAFF-producing neutrophils. PMID:25010693
4. Heteromers consisting of one BAFF and two APRIL bind to receptor TACI, BCMA but not to BAFFR. PMID:25953898
5. BCMA is dispensable for the development of SLE in NZM mice. BAFF-BCMA interactions contribute to SLE. PMID:23334904
6. Study reveals that BCMA works to control B cell homeostasis and self-tolerance in systemic autoimmunity. PMID:21536804
7. Blimp-1 is a positive regulator of the expression of BCMA gene in mouse plasma cells. PMID:20339926
8. The 5'-flanking sequence from -820 to +145 bp of BCMA is of promoter activity. PMID:18687216
9. A vital role of BCMA in bone marrow plasma cell survival. PMID:14707116
10. B cell maturation antigen, the receptor for a proliferation-inducing ligand and B cell-activating factor of the TNF family, induces antigen presentation in B cells. PMID:16116167
11. Review. APRIL interactions with BCMA likely govern memory B cell populations. PMID:16919470
12. Review. Direct BAFF/APRIL signalling in T cells and/or T cell modulation in response to a BAFF-modified B cell compartment may play an important role in inflammation and immunomodulation. PMID:16931039

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UNIGENE: Mm.12935

KEGG: mmu:21935

STRING: 10090.ENSMUSP00000023140