Mouse Tumor necrosis factor receptor superfamily member 17(TNFRSF17) ELISA kit

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Mouse Tumor necrosis factor receptor superfamily member 17(TNFRSF17) ELISA kit

Name: Mouse Tumor necrosis factor receptor superfamily member 17(TNFRSF17) ELISA kit
Brand: CUSABIO
SKU: CSB-EL023974MO

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Code: CSB-EL023974MO

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Size:

96T,5×96T,10×96T

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Quantity:

Sample Types: serum, plasma, tissue homogenates

Detect Range: 0.39 ng/ml - 25 ng/ml.

Sensitivity: 0.1 ng/ml.

Trial Size:

24T ELISA Kit Trial Size (Only USD$150/ kit)
* Sample kit cost can be deducted as a $30 credit for each 96-assay kit of the same analyte and brand you subsequently purchase within six months until depleted. More details >>

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Alternative Names

Tnfrsf17; Bcm; Bcma; Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; CD antigen CD269

Abbreviation

TNFRSF17

Uniprot NO.

O88472

Species

Mus musculus (Mouse)

Sample Type

serum, plasma, tissue homogenates

Detection Range

0.39 ng/ml - 25 ng/ml.

Sensitivity

0.1 ng/ml.

Assay Time

1-5h

Sample Loading Volume

50-100ul

Detection Wavelength

450 nm

Research Area

Immunology

Assay Principle

quantitative
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Measurement

Sandwich

Storage

Store at 2-8°C. Please refer to protocol.

Shelf Life

6 months

Lead Time

3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Precision

Linearity

To assess the linearity of the assay, samples were spiked with high concentrations of mouse TNFRSF17 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

	Sample	Serum(n=4)
1:1	Average %	99
	Range %	90-104
1:2	Average %	100
	Range %	90-105
1:4	Average %	96
	Range %	89-100
1:8	Average %	93
	Range %	89-97

Recovery

Typical Data

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

ng/ml

OD1

OD2

Average

Corrected

2.606

2.567

2.587

2.410

12.5

1.832

1.795

1.814

1.637

6.25

1.229

1.200

1.215

1.038

3.125

0.708

0.688

0.698

0.521

1.56

0.425

0.416

0.421

0.244

0.78

0.303

0.289

0.296

0.119

0.39

0.229

0.232

0.231

0.054

0.179

0.175

0.177

Troubleshooting and FAQs

ELISA kit FAQs

ELISA Data Analysis

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Description

This Mouse TNFRSF17 ELISA Kit was designed for the quantitative measurement of Mouse TNFRSF17 protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 0.39 ng/ml- 20ng/ml and the sensitivity is 0.009 ng/ml.

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Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<10%

Three samples of known concentration were tested in twenty assays to assess.

Function(From Uniprot)

Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.

Gene References into Functions

high affinity antibody blocks the binding of the native ligands APRIL and BAFF to BCMA. This finding is rationalized by the high resolution crystal structure of the Fab fragment in complex with the extracellular domain of BCMA PMID:25953704
Elimination of B lymphocyte stimulator receptor 3 (BR-3) and BCMA inhibits the development of SLE in NZM mice. PMID:25989238
we have identified a novel role for BCMA to control excess BAFF production in murine lupus through restraining the accumulation of BAFF-producing neutrophils. PMID:25010693
Heteromers consisting of one BAFF and two APRIL bind to receptor TACI, BCMA but not to BAFFR. PMID:25953898
BCMA is dispensable for the development of SLE in NZM mice. BAFF-BCMA interactions contribute to SLE. PMID:23334904
Study reveals that BCMA works to control B cell homeostasis and self-tolerance in systemic autoimmunity. PMID:21536804
Blimp-1 is a positive regulator of the expression of BCMA gene in mouse plasma cells. PMID:20339926
The 5'-flanking sequence from -820 to +145 bp of BCMA is of promoter activity. PMID:18687216
A vital role of BCMA in bone marrow plasma cell survival. PMID:14707116
B cell maturation antigen, the receptor for a proliferation-inducing ligand and B cell-activating factor of the TNF family, induces antigen presentation in B cells. PMID:16116167
Review. APRIL interactions with BCMA likely govern memory B cell populations. PMID:16919470
Review. Direct BAFF/APRIL signalling in T cells and/or T cell modulation in response to a BAFF-modified B cell compartment may play an important role in inflammation and immunomodulation. PMID:16931039