Recombinant Mouse Thrombopoietin (Thpo)

1. Increased TPO expression in HSCs following IL-11 exposure could be mimicked or blocked by inhibiting or overexpressing miR-204-5p, respectively... IL-11 promoted Hematopoietic stem cell engraftment in a mouse model of aplastic anemia an effect that was attenuated in cells overexpressing miR-204-5p. PMID:29217821
2. this study assessed the physiological source of thrombopoietin, a key cytokine required for maintaining hematopoietic stem cell . PMID:29622652
3. TPO and its receptor Mpl are dispensable for platelet survival in adult mice PMID:27344013
4. Furthermore, although the contribution of the TPO treated graft to long-term hematological engraftment was reduced, the TPO treated and untreated grafts both contributed significantly to long-term chimerism in vivo. PMID:25137252
5. TPO treatment also promoted the peripheral induction of Foxp3(+) Tregs in conjunction with elevated circulating TGF-beta levels. PMID:25212676
6. novel findings about aspects of TPO action on stem cells PMID:25564715
7. Mpl expression, but not Tpo, is fundamental in the development of JAK2V617F(+) myeloproliferative neoplasms PMID:25339357
8. Thrombopoietin/MPL signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia. PMID:25298035
9. Megakaryocytes regulate cell cycle quiescence of hematopoietic stem cell through the production of thrombopoietin. PMID:25451253
10. IEX-1 has a role in activation of Erk and NF-kB pathways, which affects thrombopoietin-promoted NHEJ DNA repair in hematopoietic stem cells PMID:24184684
11. Findings establish that Clock regulates Thpo and Mpl expression in vivo, and demonstrate an important link between the body's circadian timing mechanisms and megakaryopoiesis. PMID:22284746
12. Signal transduction pathway of ERK1/2 participates in the activation of thrombopoietin in inflammatory injury of BV2 cells. PMID:21507308
13. The implication of Tpo as a mediator of neuronal damage in experimental pneumococcal meningitis is reported. PMID:21149592
14. Administration of recombinant human IL11 after supralethal radiation exposure promotes survival in mice: interactive effect with thrombopoietin PMID:12005542
15. glycan domain of thrombopoietin acts in trans to enhance secretion of the hormone and other cytokines PMID:12101178
16. Thrombopoietin expands hematopoietic stem cells after transplantation PMID:12163458
17. p38 mitogen-activated protein kinase (MAPK) was responsible for the TPO-induced Hoxb4 elevation PMID:12855555
18. Mpl stimulation by TPO results in the activation of Lyn kinase, which appears to limit the proliferative response through a signaling cascade that regulates MAPK activity PMID:14726379
19. Thrombopoietin induces HOXA9 nuclear transport in immature hematopoietic cells PMID:15254242
20. mpl-tpo signaling pathways are negatively modulated by lnk PMID:15337790
21. is strongly proapoptotic in the brain, causing death of newly generated neurons through the Ras-extracellular signal-regulated kinase 1/2 pathway PMID:15642952
22. TPO(high) and GATA-1(low) alterations are linked in an upstream-downstream relationship along a pathobiologic pathway leading to development of myelofibrosis PMID:15665119
23. Development of myelofibrosis and osteosclerosis depends on local TPO levels in Bone marrow cells. PMID:15927672
24. Thrombopoietin synthesis is induced by IL-6 in the liver during acute inflammation. PMID:16022585
25. results suggest that a balance in positive and negative signals downstream from the TPO signal plays a role in the regulation of the probability of self-renewal in HSCs PMID:17284614
26. thrombopoietin has a role in mast cell differentiation [review] PMID:17468237
27. Chronic TPO overexpression induces mesangioproliferative glomerulopathy. PMID:17546634
28. roles for FAK in megakaryocyte growth and platelet function, setting the stage for manipulation of this component of the Tpo signaling apparatus for therapeutic benefit. PMID:17925492
29. Transcriptional regulation of bone marrow thrombopoietin by platelet proteins.( PMID:18410987
30. TPO induces HIF-1alpha expression in a manner very similar to that of hypoxia. PMID:18473128
31. thrombopoietin potentiates vasculogenesis by enhancing motility and enlivenment of transplanted endothelial progenitor cells via activation of Akt/mTOR/p70S6kinase signaling pathway PMID:18773906
32. TPO downmodulates c-Myb expression through induction of miR-150. PMID:18814950

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UNIGENE: Mm.3943

KEGG: mmu:21832

STRING: 10090.ENSMUSP00000075756