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Recombinant Mouse GDNF family receptor alpha-like (Gfral), partial

Recombinant Mouse GDNF family receptor alpha-like (Gfral), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Gfral

Purity

>85% (SDS-PAGE)

Target Names

Gfral

Uniprot NO.

Q6SJE0

Alternative Names

Gfral; Gral; GDNF family receptor alpha-like

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

20-349

Target Protein Sequence

Q TNDCAHLIQK CLIDANGCEQ SWRSMEDTCL TPGDSCKINN SLHCNLSIQA LVEKNFQFKE CLCMDDLHCT VNKLFGKKCT NKTDNMEKDN KDKWNLTTTP FYHGFKQMQS CLEVTEACVG DVVCNAQLAL YLKACSANGN LCDVKHCQAA IRFFYQNMPF NTAQMLAFCD CAQSDIPCQQ SKETLHSKPC ALNIVPPPTC LSVIHTCRND ELCRTHYRTF QTECWPHITG KCHEDETCIS MLGKQDLTCS GSESCRAAFL GTFGTVLQVP CACRGVTQAE EHVCMIFQHM LHSKSCFNYP TPNVKDISSY EKKNSKEITL TGFNSFFNG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Extracellular domain

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.

Gene References into Functions

isolating GFRAL as the receptor for GDF15-induced anorexia and weight loss, the identification of a mechanistic basis for the non-homeostatic regulation of neural circuitry by a peripheral signal associated with tissue damage and stress; findings provide opportunities to develop therapeutic agents for the treatment of disorders with altered energy demand PMID:28953886

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Subcellular Location

Cell membrane; Single-pass membrane protein; Extracellular side.

Protein Families

GDNFR family

Tissue Specificity

Expressed in the brainstem, restricted to cells in the area postrema and the immediately adjacent region of the nucleus tractus solitarius.

Database Links

UNIGENE: Mm.213862

KEGG: mmu:404194

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