Recombinant Mouse C-C motif chemokine 6 (Ccl6)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Ccl6

Uniprot NO.

P27784

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

22-116

Target Protein Sequence

GLIQEMEKE DRRYNPPIIH QGFQDTSSDC CFSYATQIPC KRFIYYFPTS GGCIKPGIIF ISRRGTQVCA DPSDRRVQRC LSTLKQGPRS GNKVIA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

CCL6(22-95) and CCL6(23-95) are potent chemoattractants.

Gene References into Functions

Mice lacking RXRalpha in myeloid cells exhibit reduced levels of CCL6 and CCL9, impaired recruitment of leukocytes to sites of inflammation, and lower susceptibility to sepsis. PMID:20498053
enhanced expression in intestinal epithelium following immunostimulation with LPS or pro-inflammatory cytokines PMID:19812544
the injury-induced expression of C10 at the mRNA and protein level PMID:11895334
c10 promotes fibrosis by recruiting macrophages in the inflammatory response to bleomycin in the lung PMID:12356575
CCL6 gene activation and production induced by SCF in the presence or absence of rather specific inhibitors for certain pathways demonstrated that the MEK/MAPK pathway but not the PI-3K pathway was crucial for the SCF-induced CCL6 gene activation. PMID:17234680
the chemokines CCL6 and CCL9 as genes prominently induced by the type I IFNs and ICSBP PMID:19171873