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Recombinant Human Neuromedin-U receptor 2 (NMUR2), partial

Recombinant Human Neuromedin-U receptor 2 (NMUR2), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

NMUR2

Purity

>85% (SDS-PAGE)

Target Names

NMUR2

Uniprot NO.

Q9GZQ4

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Receptor for the neuromedin-U and neuromedin-S neuropeptides.

Gene References into Functions

NMU might contribute to progression of NMUR2-positive breast cancer PMID:28423716
polymorphisms in the gene may be useful in identifying women at risk for osteoporosis. PMID:25871004
Study identified a novel NMUR2 splice variant lacking the third exon and able to form heteromeric complexes with NMUR1 and NMUR2 without Neuromedin U (NMU). Its expression can block NMU signaling suppressing then ovarian cancer cells proliferation. PMID:26317338
A cell-based reporter gene assay has been developed and used for the screening of the human NMU2R agonist. PMID:16781063

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 1 family

Tissue Specificity

Predominantly expressed in the CNS, particularly in the medulla oblongata, pontine reticular formation, spinal cord, and thalamus. High level in testis whereas lower levels are present in a variety of peripheral tissues including the gastrointestinal trac

Database Links

HGNC: 16454

UNIGENE: Hs.731911

KEGG: hsa:56923

STRING: 9606.ENSP00000255262

OMIM: 605108

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