NMUR2 Antibody

CSB-PA135689

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Size:

50μg100μg

US$119

Quantity:

Species Reactivity: Human

Raised in: Rabbit

Application: WB,ELISA

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Target Background

Product Details

Uniprot NO.

Q9GZQ4

Target Names

NMUR2

Alternative Names

NMUR2; NMU2R; TGR1; Neuromedin-U receptor 2; NMU-R2; G-protein coupled receptor FM-4; G-protein coupled receptor TGR-1

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from Human NMUR2. at AA range: 1-50

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Tested Applications

WB,ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Protocols

Western Blotting(WB) Protocol ELISA Protocol

Datasheet & COA

Antibody FAQs

Images

Western Blot analysis of mouse-brain cells using primary antibody diluted at 1:2000(4°C overnight). Secondary antibody:Goat Anti-rabbit IgG IRDye 800( diluted at 1:5000, 25°C, 1 hour)

Description

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Target Background

Function

Receptor for the neuromedin-U and neuromedin-S neuropeptides.

Gene References into Functions

NMU might contribute to progression of NMUR2-positive breast cancer PMID:28423716
polymorphisms in the gene may be useful in identifying women at risk for osteoporosis. PMID:25871004
Study identified a novel NMUR2 splice variant lacking the third exon and able to form heteromeric complexes with NMUR1 and NMUR2 without Neuromedin U (NMU). Its expression can block NMU signaling suppressing then ovarian cancer cells proliferation. PMID:26317338
A cell-based reporter gene assay has been developed and used for the screening of the human NMU2R agonist. PMID:16781063

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 1 family

Tissue Specificity

Predominantly expressed in the CNS, particularly in the medulla oblongata, pontine reticular formation, spinal cord, and thalamus. High level in testis whereas lower levels are present in a variety of peripheral tissues including the gastrointestinal trac

Database Links

HGNC: 16454

UNIGENE: Hs.731911

KEGG: hsa:56923

STRING: 9606.ENSP00000255262

OMIM: 605108

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