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Recombinant Human Corticotropin-releasing factor receptor 1

Recombinant Human Corticotropin-releasing factor receptor 1

Mammalian cell

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

CRHR1

Uniprot NO.

P34998

Research Area

Neuroscience

Species

Homo sapiens (Human)

Source

Baculovirus

Mol. Weight

38.3kD

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

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Target Background

Function(From Uniprot)

G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.

Subcellular Location

Cell membrane; Multi-pass membrane protein. Endosome. Note=Agonist-binding promotes endocytosis.

Protein Families

G-protein coupled receptor 2 family

Tissue Specificity

Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe.

Database Links

HGNC: 2357

UNIGENE: Hs.417628

KEGG: hsa:104909134

STRING: 9606.ENSP00000381333

OMIM: 122561