CRHR1 Antibody

CSB-PA005965EA01HU

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US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, WB, IHC, IF

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Product Details
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Target Background

Product Details

Uniprot NO.

P34998

Target Names

CRHR1

Alternative Names

Corticotropin releasing factor type 1 receptor antibody; corticotropin releasing hormone receptor 1 antibody; Corticotropin-releasing factor receptor 1 antibody; Corticotropin-releasing hormone receptor 1 antibody; CRF R antibody; crf receptor 1 antibody; crf receptor type 1 antibody; crf type 1 antibody; CRF-R antibody; CRF-R-1 antibody; CRF-R1 antibody; CRF1 antibody; CRFR antibody; CRFR-1 antibody; CRFR1 antibody; CRFR1_HUMAN antibody; CRH-R-1 antibody; CRH-R1 antibody; CRH-R1h antibody; CRHR antibody; Crhr1 antibody; CRHR1f antibody; CRHR1L antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Corticotropin-releasing factor receptor 1 protein (24-121AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Protocols

ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol Immunofluorescence (IF) Protocol

Datasheet & COA

Antibody FAQs

Images

Western blot
All lanes: CRHR1 antibody at 16µg/ml
Lane 1: Hela whole cell lysate
Lane 2: HL60 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 51, 48, 44, 47, 29 kDa
Observed band size: 51 kDa
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA005965EA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA005965EA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA005965EA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Description

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Target Background

Function

G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.

Subcellular Location

Cell membrane; Multi-pass membrane protein. Endosome. Note=Agonist-binding promotes endocytosis.

Protein Families

G-protein coupled receptor 2 family

Tissue Specificity

Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe.

Database Links

HGNC: 2357

UNIGENE: Hs.417628

KEGG: hsa:104909134

STRING: 9606.ENSP00000381333

OMIM: 122561