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Recombinant Human Corticotropin-releasing factor receptor 1 (CRHR1 ), partial

Recombinant Human Corticotropin-releasing factor receptor 1 (CRHR1 ), partial

CSB-BP005965HU

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Size:

20ug100ug1mg

US$352

Quantity:

Express system: Baculovirus

Tag Info: C-terminal 6xHis-tagged

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Target Background

Product Details

Purity

Greater than 90% as determined by SDS-PAGE.

Target Names

CRHR1

Uniprot NO.

P34998

Research Area

Neuroscience

Alternative Names

Corticotropin-releasing hormone receptor 1;CRH-R-1 ;CRH-R1

Source

Baculovirus

Expression Region

23-121aa

Target Protein Sequence

ASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVI

Mol. Weight

11.8 kDa

Protein Length

Partial

Tag Info

C-terminal 6xHis-tagged

Form

Liquid or Lyophilized powder

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function

G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.

Subcellular Location

Cell membrane; Multi-pass membrane protein. Endosome. Note=Agonist-binding promotes endocytosis.

Protein Families

G-protein coupled receptor 2 family

Tissue Specificity

Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe.

Database Links

HGNC: 2357

UNIGENE: Hs.417628

KEGG: hsa:104909134

STRING: 9606.ENSP00000381333

OMIM: 122561