RXFP4 Antibody

Code: CSB-PA274085

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Size:

50μl100μl

US$166

Quantity:

Species Reactivity: Human,Mouse

Raised in: Rabbit

Application: ELISA,WB

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Product Details
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Target Background

Product Details

Uniprot NO.

Q8TDU9

Target Names

RXFP4

Alternative Names

RXFP4; GPCR142; GPR100; RLN3R2; Relaxin-3 receptor 2; RLN3 receptor 2; G-protein coupled receptor 100; G-protein coupled receptor GPCR142; Insulin-like peptide INSL5 receptor; Relaxin family peptide receptor 4

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthetic peptide of Human RXFP4

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Tested Applications

ELISA,WB

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal lung tissue, mouse lung tissue, Primary antibody: CSB-PA274085(RXFP4 Antibody) at dilution 1/100, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation.

Gene References into Functions

The results confirmed the presence of RXFP4 in human spermatozoa, which localized in the neck and midpiece of sperm. PMID:28986276
The role of these four INSL5 determinants in distinguishing RXFP4 from RXFP3. PMID:27404393
analysis of the interaction mechanism of INSL5 with its receptor RXFP4 PMID:28274616
Relaxin-3 is a high-efficacy agonist at RXFP4 with a comparable signal transduction profile to INSL5. PMID:27888281
The C-terminus of the B-chain of human INSL5 is critical for cognate RXFP4 receptor activity. PMID:26661035
electrostatic interactions between INSL5 and RXFP4 PMID:25043977
Mutant relaxin-3 shows a significant decrease in receptor-activation potency towards RXFP4. PMID:24802387
relaxin-3/INSL7 is a ligand for GPCR142 [GPCR142] PMID:14522967
Substitution of the relaxin-3 A-chain with the A-chain from insulin-like peptide 5 results in a chimeric peptide that selectively activates GPCR135 and GPCR142. PMID:15465925
INSL5 is an endogenous ligand for GPCR142 PMID:15525639
the N-terminus and EL2 domains of RXFP3 and RXFP4 are involved in ligand binding while TM2, 3, and 5 are critical for receptor activation. PMID:18582868