RXFP4 Antibody

CSB-PA009402

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Size:

50μg100μg

US$119

Quantity:

Species Reactivity: Human

Raised in: Rabbit

Application: WB, IF, ELISA

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Product Details
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Target Background

Product Details

Uniprot NO.

Q8TDU9

Target Names

RXFP4

Alternative Names

RXFP4; GPCR142; GPR100; RLN3R2; Relaxin-3 receptor 2; RLN3 receptor 2; G-protein coupled receptor 100; G-protein coupled receptor GPCR142; Insulin-like peptide INSL5 receptor; Relaxin family peptide receptor 4

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from the C-terminal region of Human GPR100.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Tested Applications

WB, IF, ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Protocols

Western Blotting(WB) Protocol Immunofluorescence (IF) Protocol ELISA Protocol

Datasheet & COA

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Images

Western Blot analysis of A549 cells using GPR100 Polyclonal Antibody

Description

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Target Background

Function

High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation.

Gene References into Functions

The results confirmed the presence of RXFP4 in human spermatozoa, which localized in the neck and midpiece of sperm. PMID:28986276
The role of these four INSL5 determinants in distinguishing RXFP4 from RXFP3. PMID:27404393
analysis of the interaction mechanism of INSL5 with its receptor RXFP4 PMID:28274616
Relaxin-3 is a high-efficacy agonist at RXFP4 with a comparable signal transduction profile to INSL5. PMID:27888281
The C-terminus of the B-chain of human INSL5 is critical for cognate RXFP4 receptor activity. PMID:26661035
electrostatic interactions between INSL5 and RXFP4 PMID:25043977
Mutant relaxin-3 shows a significant decrease in receptor-activation potency towards RXFP4. PMID:24802387
relaxin-3/INSL7 is a ligand for GPCR142 [GPCR142] PMID:14522967
Substitution of the relaxin-3 A-chain with the A-chain from insulin-like peptide 5 results in a chimeric peptide that selectively activates GPCR135 and GPCR142. PMID:15465925
INSL5 is an endogenous ligand for GPCR142 PMID:15525639
the N-terminus and EL2 domains of RXFP3 and RXFP4 are involved in ligand binding while TM2, 3, and 5 are critical for receptor activation. PMID:18582868