NTSR2 Antibody

Code: CSB-PA985567
Size:
50μl
50μl100μl
US$166
Quantity:
Species Reactivity: Human,Mouse
Raised in: Rabbit
Application: ELISA,WB
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Product Details

Uniprot NO.
Target Names
NTSR2
Alternative Names
NTSR2; Neurotensin receptor type 2; NT-R-2; NTR2; Levocabastine-sensitive neurotensin receptor
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthetic peptide of Human NTSR2
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Tested Applications
ELISA,WB
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Datasheet & COA
Images
  • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: CSB-PA985567(NTSR2 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 90 seconds

Customer Reviews and Q&A

 Customer Reviews

Target Background

Function(From Uniprot)
Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Gene References into Functions
  1. We showed that expression levels for NTS and NTSR1 varied, that NTSR2 expression was not detectable and that NTSR3 was consistently expressed in all CRC cell lines examined. PMID:28498396
  2. high expression of NTSR1 is found in clinical NETs and promoter methylation is an important mechanism controlling the differential expression of NTSR1 and silencing of NTSR2 in NET cells PMID:26298774
  3. NTSR2 was overexpressed, NTSR1 decreased, and neurotensin was not expressed in B cell leukemia patient's B-cells, as compared with healthy B cells. PMID:23109725
  4. this study proposes a novel function of NTR2 in the regulation of NTR1 activity. PMID:19968961
  5. NTR2 and NTR3 were upregulated in prostate cancer cells with luminal phenotype (cytokeratin 18+) PMID:20048080
  6. Recycling ability depends on a single tyrosine residue PMID:11801734
  7. ghrelin receptor, neurotensin receptor 2 and GPR39 display an unusually high degree of constitutive activity, determined by an aromatic cluster on the inner face of the extracellular ends of TMs VI and VII PMID:15383539
  8. NTR1 and NTR2 mRNA were not detected in either pituitary adenomas or normal tissue. PMID:18624930

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 1 family, Neurotensin receptor subfamily, NTSR2 sub-subfamily
Tissue Specificity
Expressed in prostate (at protein level).
Database Links

HGNC: 8040

UNIGENE: Hs.131138

KEGG: hsa:23620

STRING: 9606.ENSP00000303686

OMIM: 605538

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