Il18bp Antibody

CSB-PA16769A0Rb

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20μg50μg100μg

US$83

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Species Reactivity: Mouse

Raised in: Rabbit

Application: ELISA, IHC

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Target Background

Product Details

Uniprot NO.

Q9Z0M9

Target Names

Il18bp

Alternative Names

Il18bp antibody; Igifbp antibody; Interleukin-18-binding protein antibody; IL-18BP antibody; Interferon gamma-inducing factor-binding protein antibody

Raised in

Rabbit

Species Reactivity

Mouse

Immunogen

Recombinant Mouse Interleukin-18-binding protein (29-193AA)

Immunogen Species

Mus musculus (Mouse)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:10-1:100

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Protocols

ELISA Protocol Immunohistochemistry (IHC) Protocol

Datasheet & COA

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Images

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA16769A0Rb at dilution of 1:20

Description

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Target Background

Function

Binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response.

Gene References into Functions

IL-18BP ameliorates cardiac ischemia/reperfusion injury in part through suppression of Th17 differentiation. PMID:26340315
Data show that IL-18bp acts as a sensor for IFN-gamma and can regulate both Th1 and Th17 responses in the CNS. PMID:20644165
Administratioan of murine IL-18BP at the time of the booster injection of bovine CII reduces the progressive severity of collagen-induced arthritis; both clinical disease activity and histological scores are decreased by 50%. PMID:12574381
functional polarization of Ag-specific CD4(+) Th2 cells entering the CNS during the accelerating phase of experimental autoimmune encephalomyelitis is flexible and dependent on IL-18, which is overturned by IL-18 binding protein PMID:15778395
IL-18 and IL-18BP may have roles in testicular development, and also in the regulation of testicular functions under physiological conditions PMID:18299271
A single intravenous dose of recombinant mouse IL18BP decreased neointimal hyperplasia and improved arterial L/A ratios in an atherosclerotic balloon-injury animal model. PMID:18455646