Hras Antibody, Biotin conjugated

Code: CSB-PA15539D0Rb
Size:
50μg
50μg100μg
US$166
Quantity:
Species Reactivity: Rat
Raised in: Rabbit
Application: ELISA
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Product Details

Uniprot NO.
Target Names
Hras
Alternative Names
Hras antibody; Hras1 antibody; GTPase HRas antibody; H-Ras-1 antibody; Transforming protein p21 antibody; c-H-ras antibody; p21ras) [Cleaved into: GTPase HRas antibody; N-terminally processed] antibody
Raised in
Rabbit
Species Reactivity
Rat
Immunogen
Recombinant Rat GTPase HRas protein (2-186AA)
Immunogen Species
Rattus norvegicus (Rat)
Conjugate
Biotin
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Tested Applications
ELISA
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Datasheet & COA

Customer Reviews and Q&A

 Customer Reviews

Target Background

Function(From Uniprot)
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
Gene References into Functions
  1. Together, these results suggest a novel mechanism regulating PATZ1 expression based on the upregulation of miR-29b expression induced by Ras oncogene. PMID:27125250
  2. H-ras isoform mediates protection against pressure overload-induced cardiac dysfunction in part through activation of AKT/PI3K signaling pathway. PMID:28193718
  3. Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers. PMID:26568031
  4. H-Ras mediates the inhibitory effect of epidermal growth factor on the epithelial Na+ channel PMID:25774517
  5. Data indicate that numerous proteins that are up-regulated in H-ras(G12V) transgenic rat pancreatic ductal adenocarcinoma (PDAC) are also up-regulated in human PDAC; therefore, this rat model can be used for diagnostic biomarkers for this disease. PMID:23648844
  6. Fe(2+)-generated O(2) mediates p21(ras) and TAK1 activation via PTP inhibition and Lys(63)-polyUb of TRAF6 in caveosomes for proinflammatory M1 activation in hepatic macrophages PMID:22829592
  7. The proto-oncogenic H-Ras is directly involved in the promotion of muscle differentiation via PI3K and its downstream signaling pathways. PMID:20603646
  8. Data show that Myc repressed Ras-induced senescence, and that Cdk2 interacted with Myc at promoters, where it affected Myc-dependent regulation of genes, including those of proteins known to control senescence. PMID:19966300
  9. We examined if H-Ras and K-Ras proteins, which are distributed across different plasma membrane microdomains, have equal access to the endocytic compartment and whether this access is necessary for downstream signaling. PMID:12077341
  10. A positive regulatory role of Ras is observed in AMPA receptor-mediated synaptic transmission in hippocampal pyramidal neurons. PMID:12824760
  11. Functional activation of H-Ras might be one of the signaling steps involved in glucose-induced capillary cell apoptosis. PMID:14988264
  12. Silencing of individual genes by DNA methylation is controlled by HRAS oncogenic signalling pathways, yet the mechanisms responsible for initial target gene suppression are variable. PMID:16568090
  13. H-ras suppresses integrin affinity via independent Raf and phospholipase C epsilon signaling pathways. PMID:16895916
  14. analysis of tumor induction with expression plasmids for activated H-ras and c-myc PMID:18218323
  15. Infection with M. arginini made rat and mouse embryo fibroblasts susceptible to transformation with oncogenic H-Ras PMID:18408766
  16. induction of long-term potentiation triggered robust Ca2+-dependent Ras activation in single spines that decayed in approximately 5 minutes; Ras activity spread over approximately 10 micrometers of dendrite and invaded neighboring spines by diffusion PMID:18556515
  17. trend of increased H-ras expression was observed in diabetic compared to normal rats during oncogenesis PMID:19283661

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Subcellular Location
Cell membrane. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Golgi apparatus membrane; Lipid-anchor.
Protein Families
Small GTPase superfamily, Ras family
Database Links

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