GUCA2B Antibody

Code: CSB-PA613693GA01HU

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Size:

100μl

US$600

Quantity:

Species Reactivity: human,Mouse,Rat

Raised in: Rabbit

Application: ELISA,WB

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Target Background

Product Details

Uniprot NO.

Q16661

Target Names

GUCA2B

Alternative Names

GUCA2B antibody; GCAP II antibody; GCAP-II antibody; Guanylate cyclase activator 2B (uroguanylin) antibody; Guanylate cyclase activator 2B antibody; Guanylate cyclase C-activating peptide II antibody; GUC2B_HUMAN antibody; GUCA2B antibody; UGN antibody; Uroguanylin antibody

Raised in

Rabbit

Species Reactivity

human,Mouse,Rat

Immunogen

Human uroguanylin

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol Western Blotting(WB) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.

Gene References into Functions

The simulations suggested that all missense SNPs considered as convergent deleterious caused some kind of structural change to the uroguanylin peptide. Additionally, four of these SNPs were also shown to cause modifications in peptide flexibility, possibly resulting in functional changes. PMID:27620667
Uroguanylin concentrations are increased in patients with chronic renal failure, nephrotic syndrome, or those on dialysis. PMID:15780094
The occurrences of the C-A haplotype (rs883062-rs1047047) and the C-A-G haplotype (rs883062-rs1047047-rs2297566) were significantly higher in the essential hypertension group than in the controls. PMID:18037771

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Subcellular Location

Secreted.

Protein Families

Guanylin family

Tissue Specificity

Stomach and intestine.

Database Links

HGNC: 4683

UNIGENE: Hs.32966

KEGG: hsa:2981

STRING: 9606.ENSP00000361662