GPA33 Antibody

Code: CSB-PA055320
Size:
50μl
50μl100μl
US$166
Quantity:
Species Reactivity: Human
Raised in: Rabbit
Application: ELISA,WB,IHC
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Product Details

Uniprot NO.
Target Names
GPA33
Alternative Names
A33 antibody; Cell surface A33 antigen antibody; Cell surface A33 antigen precursor antibody; Glycoprotein A33 (transmembrane) antibody; Glycoprotein A33 antibody; Gpa33 antibody; GPA33_HUMAN antibody; MGC129986 antibody; MGC129987 antibody; OTTHUMP00000032346 antibody; Transmembrane glycoprotein A33 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Fusion protein of Human GPA33
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Tested Applications
ELISA,WB,IHC
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Datasheet & COA
Images
  • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA055320(GPA33 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA055320(GPA33 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • Gel: 15%SDS-PAGE, Lysate: 40 μg, Lane 1-3: 293T cells, human colon cancer tissue, 231 cells, Primary antibody: CSB-PA055320(GPA33 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds

Customer Reviews and Q&A

 Customer Reviews

Target Background

Function(From Uniprot)
May play a role in cell-cell recognition and signaling.
Gene References into Functions
  1. A33 shows similar sensitivity to but is more specific than CDX2 as an immunomarker of colorectal carcinoma PMID:28226180
  2. A33 expression is directly correlated to colorectal tumor differentiation. PMID:27272411
  3. Data indicate that EpCAM- and A33-Exos were released from the apical and basolateral surfaces, respectively. PMID:23230278
  4. Data indicate positive staining was observed for both A33 expression and KRN330 binding from patients biopsied on Day 8, 9 or 14 following initial dosing of 3 mg/kg. PMID:23294608
  5. The A33-dependent incorporation of B5 into extracellular enveloped vaccinia virions is mediated through an interaction between their lumenal domains. PMID:22623777
  6. Increased interaction between vaccinia virus proteins A33 and B5 is detrimental to infectious extracellular enveloped virion production. PMID:22623782
  7. cloning, chromosomal localizations, exon-intron structures and transcription start sites - target gene for the intestine-specific homeobox transcription factor, CDX1. PMID:12114523
  8. Regulation of A33 antigen expression by GKLF. PMID:12853980
  9. This work has demonstrated that the antigen is both highly immobile and extremely persistent-retaining its surface localization for a turnover halflife of greater than 2 days. PMID:18236042

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Subcellular Location
Membrane; Single-pass type I membrane protein.
Tissue Specificity
Expressed in normal gastrointestinal epithelium and in 95% of colon cancers.
Database Links

HGNC: 4445

UNIGENE: Hs.651244

KEGG: hsa:10223

STRING: 9606.ENSP00000356842

OMIM: 602171

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