Recombinant Human Claudin-9 (CLDN9)-VLPs (Active)

CSB-MP005511HU

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Size:

20ug100ug1mg

US$558

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Express system: Mammalian cell

Species: Homo sapiens (Human)

Tag Info: C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)

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Target Background

Product Details

Endotoxin

Less than 1.0 EU/ug as determined by LAL method.

Activity

Measured by its binding ability in a functional ELISA. Immobilized Human CLDN9 at 10 μg/mL can bind Anti-CLDN6/9 recombinant antibody (CSB-RA005508MA1HU), the EC₅₀ is 24.93-35.47 ng/mL.

Target Names

CLDN9

Uniprot NO.

O95484

Molecular Characterization

Species

Homo sapiens (Human)

Source

Mammalian cell

Expression Region

1-217aa

Target Protein Sequence

MASTGLELLGMTLAVLGWLGTLVSCALPLWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVIALLLALLGLLVAITGAQCTTCVEDEGAKARIVLTAGVILLLAGILVLIPVCWTAHAIIQDFYNPLVAEALKRELGASLYLGWAAAALLMLGGGLLCCTCPPPQVERPRGPRLGYSIPSRSGASGLDKRDYV

Mol. Weight

24.2 kDa

Protein Length

Full Length

Tag Info

C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)

Buffer

Lyophilized from a 0.2 μm filtered PBS, 6% Trehalose, pH 7.4

Storage

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Lead Time

Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Shelf Life

The shelf life is related to many factors, storage state, storage temperature and the stability of the product itself. Generally, the shelf life of lyophilized form is 6 months at -20°C/-80°C from the date of receipt.

Troubleshooting and FAQs

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Datasheet & COA

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Images

CSB-MP005511HU is detected by Mouse anti-6*His monoclonal antibody.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CLDN9 at 10 μg/ml can bind Anti-CLDN6/9 recombinant antibody (CSB-RA005508MA1HU), the EC₅₀ is 24.93-35.47 ng/mL.

Description

This Human Claudin-9 (CLDN9) recombinant protein was produced in Mammalian cell, where the gene sequence encoding Human CLDN9 (1-217aa) was expressed with the C-terminal 10xHis tag. The activity was validated.
In addition, this Human CLDN9 recombinant protein was developed through the Virus-Like Particles (VLPs) Platform. It is a four-pass transmembrane protein.

CLDN9 (Claudin-9) is located on human chromosome 16p13.3, with a full length of 651 bases. The CLDN9 gene is overexpressed in the blood, pituitary and brain, and is highly expressed in endometrial cancer, liver cancer and gastric cancer cell lines. CLDN9 protein is mainly Localized at cell tight junctions, cell membranes and channel proteins.
CLDN9 is a tight junction protein. Abnormal expression of CLDN9 will lead to impaired tight junctions function and reduced barrier function, resulting in increased tissue permeability, which will eventually lead to many diseases including hereditary, allergic diseases, infectious diseases of various systems and even tumors. Therefore, CLDN9 is regarded as a potential target for the treatment of cancer or other diseases.

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Target Background

Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.; (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.

Gene References into Functions

CLDN9 may be an important biomarker for invasive pituitary oncocytomas. PMID:25281028
Claudins 6, 7, and 9 expressions are closely related to gastric carcinogenesis. PMID:19960275
Mouse studies suggest that claudin-9 deficiency may cause hearing loss not only in mice but also in humans. PMID:19696885
Residues N38 and V45 in the first extracellular loop (EL1) of CLDN9 are necessary for HCV entry. PMID:17804490
CLDN9, clustered with CLDN6 at human chromosome 16p13.3, is a four-transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C. PMID:12736707