ASGR2 Antibody

Code: CSB-PA002208ZA01MO

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20μl50μl100μl

US$83

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Species Reactivity: Mus musculus

Raised in: Rabbit

Application: ELISA, WB

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Target Background

Product Details

Uniprot NO.

P24721

Target Names

ASGR2

Alternative Names

Asgr2; Asgr-2; Asialoglycoprotein receptor 2; ASGP-R 2; ASGPR 2; Hepatic lectin 2; HL-2; mHL-2

Raised in

Rabbit

Species Reactivity

Mus musculus

Immunogen

Recombinant Mouse Asialoglycoprotein receptor 2 (Asgr2), Partial (80-301AA)

Immunogen Species

Mus musculus (Mouse)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Protein A/G

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-4 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western Blot
Positive WB detected in Recombinant protein
All lanes: ASGR2 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 45.9 kDa
Observed band size: 52 kDa

Description

The process of generating the ASGR2 polyclonal antibody adheres to a well-structured procedure. It commences with the repeated immunization of a rabbit using recombinant mouse ASGR2 protein (80-301aa), continuing until the desired antibody titer is reached. Subsequently, the rabbit's blood is collected, and the antibodies are meticulously purified from the serum using protein A/G. The functionality of the resulting ASGR2 antibody is thoroughly assessed through ELISA and WB applications, confirming its specific reactivity with the mouse ASGR2 protein.

The ASGR2 protein is a crucial component of the asialoglycoprotein receptor (ASGPR), facilitating the recognition, uptake, and clearance of desialylated glycoproteins and glycolipids from the bloodstream, particularly in the liver. This function is vital for maintaining metabolic homeostasis and overall health.

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Target Background

Function(From Uniprot)

Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Gene References into Functions

ASGP-R2 mediates the clearance of glycoproteins that bear oligosaccharides terminating with Siaalpha2,6Gal and thereby helps maintain the relative concentrations of these glycoproteins in the blood. PMID:19075021

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Subcellular Location

Membrane; Single-pass type II membrane protein.

Tissue Specificity

Expressed exclusively in hepatic parenchymal cells.

Database Links

UNIGENE: Mm.1357

KEGG: mmu:11890

STRING: 10090.ENSMUSP00000099632

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