WNT5A

WNT5A, or Wnt family member 5A, is a secreted glycoprotein with a molecular weight of approximately 38 kDa, composed of five exons and containing multiple polyadenylation sites. WNT5A can activate the atypical Wnt signaling pathway by binding to Frizzled family receptors and orphan tyrosine kinase receptor 2, regulating cytoskeleton, cell polarity, and migration through various signaling pathways. WNT5A plays a crucial role in numerous physiological and pathological activities, including embryonic development, inflammatory responses, and tumor development. It is involved in cell polarity, directed movement, cytoskeleton deformation, and the malignant progression of various tumors. The WNT5A protein has paradoxical functions, acting as both an oncogene and a tumor suppressor gene, participating in multiple cellular and physiological processes by regulating several atypical signaling pathways.