TF

Transferrin (TF) is an important β-globulin that primarily functions as a transporter of iron ions in the blood plasma. Its structure consists of a single-chain glycoprotein with a molecular weight of approximately 77,000 and a carbohydrate content of about 6%. This protein exhibits the unique ability to reversibly bind multiple ions, particularly iron ions, with each molecule capable of binding two trivalent iron atoms, thereby facilitating efficient iron ion transport within the body. Functionally, transferrin not only transports iron in the form of the TRF-Fe3+ complex to the bone marrow for the production of mature red blood cells, but also forms stable complexes with iron ions during iron excess, preventing toxic accumulation and oxidative damage. Additionally, it plays a crucial role in regulating the balance of iron ions in the body, ensuring that the iron needs of cells and tissues are met, thus maintaining iron homeostasis. Notably, transferrin, through its interaction with transferrin receptor (TfR), has the potential to activate signaling pathways involved in cell proliferation, differentiation, apoptosis, and immune responses, providing a novel targeting agent for tumor cell diagnosis and treatment. However, further research is warranted to fully understand the detailed mechanisms of the transferrin signaling pathway and its role in biological organisms.

Popular Product:

Recombinant Human Tissue factor (F3), partial

Validated Data

SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

LCMS

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP007928HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) F3.

LCMS

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP007928HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) F3.