Recombinant Bovine Alpha-synuclein (SNCA)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

SNCA

Purity

>85% (SDS-PAGE)

Target Names

SNCA

Uniprot NO.

Q3T0G8

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

1-140

Target Protein Sequence

MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GRTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGEAV VTGVTAVAQK TVEGAGSIAA ATGFGKKDHM GKGEEGASQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.

Gene References into Functions

analysis of membrane curvature sensing by amphipathic helices using alpha-synuclein and annexin B12 [ANXB12] PMID:21953452
Immunocytochemistry shows alpha synuclein localized to the Golgi apparatus and vesicles of bovine adrenal medullary chromaffin cells, consistent with its putative role in vesicular function within synapses. PMID:12932858

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Subcellular Location

Cytoplasm. Membrane. Nucleus. Cell junction, synapse. Secreted.

Protein Families

Synuclein family

Database Links

UNIGENE: Bt.12770

KEGG: bta:282857

STRING: 9913.ENSBTAP00000021300

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