The gene PTH1R encodes the Parathyroid Hormone 1 Receptor (PTH1R), also known as the Parathyroid Hormone/Parathyroid Hormone-related Protein Receptor (PTH/PTHrP type 1 receptor). This receptor is a G protein-coupled receptor (GPCR) that plays a crucial role in regulating calcium and phosphorus homeostasis. PTH1R binds to parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP), leading to the activation of intracellular signaling pathways. These pathways include the GαS-adenylyl cyclase-cAMP-protein kinase A (PKA) pathway, which is essential for the regulation of blood calcium levels. PTH1R mutations are associated with various diseases, including Eiken syndrome, a rare condition characterized by delayed bone mineralization. The development of drugs targeting PTH1R is ongoing, with the aim of treating conditions such as hypoparathyroidism and osteoporosis.
Popular
Product:
Recombinant Human Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R), partial (Active)(CSB-MP018988HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human PTH1R at 2 μg/ml can bind Anti-PTH1R recombinant antibody (CSB-RA018988MA1HU). The EC50 is 0.7813-1.048 ng/mL.
PTH1R Recombinant Monoclonal Antibody (CSB-RA018988MA1HU) captured on Protein A Chip can bind Recombinant Human PTH1R protein with an affinity constant of 0.14 nM as detected by MetaSPR Assay (WeSPRTM 200).
PTH1R Recombinant Monoclonal Antibody(CSB-RA018988MA1HU)
Validated Data
The Binding Activity of Human PTH1R with Anti-PTH1R recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human PTH1R(CSB-MP018988HU) at 2 μg/mL can bind Anti-PTH1R recombinant antibody. The EC50 is 0.7813-1.048 ng/mL.
The Binding Activity of Rat Pth1r with Anti-PTH1R recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Rat Pth1r（CSB-MP018988RA2） at 2 μg/mL can bind Anti-PTH1R recombinant antibody. The EC50 is 0.7384-1.203 ng/mL.
The Binding Activity of Macaca fascicularit PTH1R with Anti-PTH1R recombinant antibody
Activity: Measured by its binding ability in a functional ELISA.Immobilized Macaca fascicularit PTH1R(CSB-MP018988MOV4) at 2 μg/mL can bind Anti-PTH1R recombinant antibody. The EC50 is 1.072 to 1.403 ng/mL.
The Binding Activity of Macaca fascicularit PTH1R with Anti-PTH1R recombinant antibody
Activity: Measured by its binding ability in a functional ELISA.Immobilized Macaca fascicularit PTH1R(CSB-MP018988MOV4) at 2 μg/mL can bind Anti-PTH1R recombinant antibody. The EC50 is 1.072 to 1.403 ng/mL.
The following PTH1R
reagents supplied by CUSABIO are manufactured under a
strict quality control system. Multiple applications
have been validated and solid technical support is
offered.
