LEP, or leptin, is known by the aliases FLJ94114, LEPD, leptin, OB, and OBS. LEP is encoded by the human LEP gene, which is located on chromosome 7 at position p13. LEP is a hormone secreted predominantly by the white adipose tissue, and it produces its biological effects by binding to its receptor, LEPR, or OB-R.
The mechanism of action of LEP involves the regulation of food intake, energy expenditure, and fat metabolism, as well as participation in energy balance and body weight regulation through binding to its corresponding receptors in the hypothalamus.
LEP not only plays a major role in the regulation of fat storage, but also plays a role in physiological processes, such as growth and reproduction, and is gradually being emphasized in relation to neuroendocrinology, vascular neogenesis, immunomodulation and trauma repair. The role of LEP has also been widely studied in obesity, diabetes, cardiovascular disease and ischemia-reperfusion injury.
Popular
Product:
LEP Antibody(CSB-PA06799A0Rb)
Validated Data
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA06799A0Rb at dilution of 1:10
Immunofluorescent analysis of Hela cells using CSB-PA06799A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
The following LEP
reagents supplied by CUSABIO are manufactured under a
strict quality control system. Multiple applications
have been validated and solid technical support is
offered.
LEP Proteins
LEP Proteins for Pongo pygmaeus (Bornean orangutan)
LEP Proteins for Phoca vitulina (Harbor seal)
LEP Proteins for Pan troglodytes (Chimpanzee)
LEP Proteins for Gallus gallus (Chicken)
LEP Proteins for Equus caballus (Horse)
LEP Proteins for Homo sapiens (Human)
LEP Proteins for Sus scrofa (Pig)
LEP Proteins for Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
LEP Proteins for Macaca mulatta (Rhesus macaque)
LEP Proteins for Bos taurus (Bovine)
LEP Proteins for Sminthopsis crassicaudata (Fat-tailed dunnart) (Phascogale crassicaudata)
LEP Proteins for Bubalus bubalis (Domestic water buffalo)
LEP Proteins for Ursus thibetanus (Asiatic black bear) (Selenarctos thibetanus)
LEP Proteins for Gorilla gorilla gorilla (Western lowland gorilla)
LEP Proteins for Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
LEP Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
LEP Proteins for Ovis aries (Sheep)
LEP Proteins for Felis catus (Cat) (Felis silvestris catus)
LEP Proteins for Rattus norvegicus (Rat)
LEP Proteins for Arabidopsis thaliana (Mouse-ear cress)
LEP Proteins for Halichoerus grypus (Gray seal)
LEP Proteins for Meleagris gallopavo (Wild turkey)
LEP Proteins for Mus musculus (Mouse)
LEP Proteins for Capra hircus (Goat)
LEP ELISA Kit
LEP ELISA Kit for Ovis aries (Sheep)
LEP ELISA Kit for Gallus gallus (Chicken)
LEP ELISA Kit for Equus caballus (Horse)
LEP ELISA Kit for Rattus norvegicus (Rat)
LEP ELISA Kit for Homo sapiens (Human)
LEP ELISA Kit for Sus scrofa (Pig)
LEP ELISA Kit for Bos taurus (Bovine)
LEP ELISA Kit for Mus musculus (Mouse)
LEP ELISA Kit for Capra hircus (Goat)
