GLP2R

The protein corresponding to the gene GLP2R is the Glucagon-like peptide 2 receptor, also commonly known as GLP-2R. This receptor specifically binds glucagon-like peptide 2 (GLP-2), a hormone secreted by the intestinal endocrine L-cells. Activation of GLP2R stimulates cell proliferation in the intestinal mucosa, enhances nutrient absorption, and promotes gut barrier function through the cAMP - PKA signaling pathway.
Dysregulation of GLP2R is associated with conditions like short - bowel syndrome. In drug development, agonists of GLP2R have been explored to treat intestinal diseases. Teduglutide, a GLP - 2 analog, has been approved to improve intestinal absorption in short - bowel patients, showing the therapeutic potential of targeting GLP2R.