ADIPOQ

ADIPOQ, the Adiponectin, is also known as ACRP30, apM1, GBP28. ADIPOQ is encoded by the human ADIPOQ gene, which is located in the 3q27 region of chromosome 3. ADIPOQ activates the p38 mitogen-activated protein kinase (MAPK) through the binding of its receptor to activate the and then exerts biological effects such as amelioration of insulin resistance, hypoglycemia, and anti-inflammation.
ADIPOQ is strongly associated with obesity, insulin resistance, type 2 diabetes mellitus, and cardiovascular disease, and its plasma concentration is usually significantly decreased in patients with these diseases, negatively correlates with body weight, fat distribution, fasting insulin concentration, and glucose tolerance test, and positively correlates with insulin sensitivity, and is a diagnostic indicator of these diseases.