VSIR (KVA-12.1 Biosimilar) Recombinant Monoclonal Antibody

Code: CSB-RA884484MB2HU

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Size:

100ug

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US$199

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Species Reactivity: Human

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Target Background

Product Details

Uniprot NO.

Q9H7M9

Alternative Names

KVA12.1 research-grade biosimilar; KVA 12.1 research-grade biosimilar; KVA-12.1 research-grade biosimilar; KVA12123 research-grade biosimilar; TBS-2025 research-grade biosimilar ;VSIR antibody; C10orf54 antibody; SISP1 antibody; VISTA antibody; PP2135 antibody; UNQ730/PRO1412 antibody; V-type immunoglobulin domain-containing suppressor of T-cell activation antibody; Platelet receptor Gi24 antibody; Stress-induced secreted protein-1 antibody; Sisp-1 antibody; V-set domain-containing immunoregulatory receptor antibody; V-set immunoregulatory receptor antibody

Species Reactivity

Human

Immunogen

Recombinant Human VSIR protein

Conjugate

Non-conjugated

Clonality

Monoclonal

Buffer

0.01M PBS，pH7.4

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Notes

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Lead Time

3-4 weeks
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Concentration

It differs from different batches. Please contact us to confirm it.

Usage

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Datasheet & COA

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Description

This recombinant monoclonal antibody is a research-grade biosimilar of KVA-12.1, targeting VSIR (also known as VISTA, V-domain Ig suppressor of T cell activation)—a type I transmembrane immunoregulatory receptor that functions as an immune checkpoint. VISTA is prominently associated with myeloid-lineage cells (including MDSCs, monocytes/macrophages) and is also described on T-cell compartments (notably including naïve T cells), where it helps maintain immune quiescence and suppress excessive activation. In tumor settings, VISTA-linked signaling is frequently discussed as a contributor to myeloid-mediated immunosuppression and an axis of checkpoint resistance biology within the tumor microenvironment.

KVA-12.1 is described as a fully human anti-VISTA monoclonal antibody being developed for immuno-oncology, including evaluation in monotherapy and combination with anti–PD-1 strategies. This biosimilar provides the antibody component alone, enabling researchers to investigate VISTA checkpoint biology—such as VISTA-associated suppression of T-cell effector function, regulation of MDSC-mediated inhibition, and target engagement effects on myeloid/T-cell crosstalk—independent of other therapeutic agents. It also supports assay development around VISTA–ligand pathway modulation (e.g., interactions reported with partners like PSGL-1 or VSIG3) and exploratory studies evaluating VISTA/VSIR as a biomarker or mechanistic driver in immunosuppressive microenvironments.

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Target Background

Function(From Uniprot)

Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. May stimulate MMP14-mediated MMP2 activation.

Gene References into Functions

Data indicate that VISTA is predominantly expressed and up-regulated in the high-density infiltrated immune cells but minimal in pancreatic cancerous cells. PMID:29771768
High VISTA expression is associated with colorectal carcinoma. PMID:30128738
VISTA expression supports immune-complex inflammation in collagen antibody-induced arthritis and VISTA is expressed in human synovium PMID:29216931
This study is the first to describe the expression of VISTA-expressing lymphocytes in melanoma samples and in the context of acquired resistance to immune checkpoint inhibitors PMID:28776578
Taken together, the results indicated that the VISTA high and CD8 low group, as an immunosuppressive subgroup, might be associated with a poor prognosis in primary OSCC. These findings indicated that VISTA might be a potential immunotherapeutic target in OSCC treatment. PMID:28236118
this review describes the functions of VISTA in the context of cancer immunotherapy PMID:28258694
overexpression of the newly described co-stimulatory molecule, PD1 homologue (PD-1H) in human monocyte/macrophages is sufficient to induce spontaneous secretion of multiple cytokines. PMID:25279955
p53-induced expression of DD1alpha prevents persistence of cell corpses and ensures efficient generation of precise immune responses in mice. PMID:26228159
Results suggest that GI24 contributes to tumor-invasive growth in the collagen matrix by augmenting cell surface MT1-MMP. PMID:20666777

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Tissue Specificity

Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at high levels in placenta

Database Links

HGNC: 30085

UNIGENE: Hs.47382

KEGG: hsa:64115

STRING: 9606.ENSP00000378409

OMIM: 615608

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