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RGMA (Elezanumab Biosimilar) Recombinant Monoclonal Antibody

RGMA (Elezanumab Biosimilar) Recombinant Monoclonal Antibody

Code: CSB-RA836186MB1HU

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Size:

100ug

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US$199

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Species Reactivity: Human

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Product Details
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Target Background

Product Details

Uniprot NO.

Q96B86

Alternative Names

ABT-555 research-grade biosimilar; AE12-1Y-QL research-grade biosimilar; Elezanumab research-grade biosimilar; Elezanumab (USAN/INN) research-grade biosimilar; PR-1432051 research-grade biosimilar ;RGMA antibody; RGM antibody; Repulsive guidance molecule A antibody; RGM domain family member A antibody

Species Reactivity

Human

Immunogen

Recombinant Human RGMA protein

Conjugate

Non-conjugated

Clonality

Monoclonal

Buffer

0.01M PBS，pH7.4

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Notes

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Lead Time

3-4 weeks
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Concentration

It differs from different batches. Please contact us to confirm it.

Usage

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Datasheet & COA

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Description

This recombinant monoclonal antibody is a research-grade biosimilar to elezanumab, designed for research applications targeting repulsive guidance molecule A (RGMA). RGMA is a glycosylphosphatidylinositol-anchored protein that functions as an axonal growth inhibitor by binding to neogenin receptors. It plays a critical role in neural development and axon guidance during embryogenesis. In the adult central nervous system, RGMA contributes to the inhibition of axonal regeneration following injury and has been implicated in neurodegenerative conditions. Elevated RGMA expression has been associated with multiple sclerosis, spinal cord injury, and stroke, where it limits neuronal repair and functional recovery.

Elezanumab is a humanized IgG1 monoclonal antibody that neutralizes RGMA activity, thereby promoting axonal growth and potentially enhancing neural repair mechanisms. This biosimilar antibody serves as a valuable tool for investigating RGMA-mediated signaling pathways, studying axon regeneration mechanisms, and exploring therapeutic strategies for neurological disorders characterized by impaired neural plasticity. It enables researchers to examine the role of RGMA in disease models and evaluate potential neuroprotective interventions.

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Target Background

Function(From Uniprot)

Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Gene References into Functions

Dysregulation of RGMa plays an important role in the pathology of Parkinson's disease. PMID:28842419
Thus, we conclude that RGMa inhibits angiogenesis in vitro and in vivo suggesting that its manipulation would be an efficient therapeutic strategy for pro-angiogenic conditions. PMID:26721439
RGMa expression and promoter methylation status are closely related to colorectal cancer genesis and progression. PMID:22367090
identification of neogenin-binding site on the repulsive guidance molecule A PMID:22396795
The expression of RGMA, RGMB and RGMC was evident in most examined prostate cancer cell lines, and also in the prostate cancer tissues PMID:22076499
Reduced expression of RGMA in breast cancer was associated with breast cancer. PMID:21617229
The full-length signal peptides of RGMa is functional and furthermore that the C-domains are sufficient and essential for ER targeting, whereas the N-domains are dispensable. Thus, the N-domains are available for additional functions. PMID:21183991
RGM-A is a unique endogenous inhibitor of leukocyte chemotaxis that limits inflammatory leukocyte traffic PMID:21467223
Following central nervous system injury, RGM, a novel, potent axonal growth inhibitor, is present in axonal growth impediments: the mature myelin, choroid plexus, and components of the developing scar. PMID:16216939
RGMa facilitates the use of ActRIIA by endogenous BMP2 and BMP4 ligands that otherwise prefer signaling via BMPRII and increased utilization of ActRIIA leads to generation of an enhanced BMP signal PMID:17472960
detected a homozygous deletion of chromosomal region 15q26.2 in the cell line HDLM2 encompasing RGMA and CHD2 PMID:17606441
this study, we show that Unc5B, a member of the netrin receptor family, interacts with neogenin as a coreceptor for RGMa. PMID:19273616
Frequent inactivation of axon guidance molecule RGMA in human colon cancer through genetic and epigenetic mechanisms. PMID:19303019