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IL1RL2 (Spesolimab Biosimilar) Recombinant Monoclonal Antibody

IL1RL2 (Spesolimab Biosimilar) Recombinant Monoclonal Antibody

Code: CSB-RA888016MB2HU

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Size:

100ug

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US$199

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Species Reactivity: Human

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Product Details
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Target Background

Product Details

Uniprot NO.

Q9HB29

Alternative Names

BI 655130 research-grade biosimilar; BI-655130 research-grade biosimilar; Immunoglobulin G1, anti-(human interleukin 36 receptor) (humanized monoclonal BI 655130 gamma1-chain), disulfide with humanized monoclonal BI 655130 kappa-chain, dimer research-grade biosimilar; Spesolimab research-grade biosimilar; Spesolimab (genetical recombination) (JAN) research-grade biosimilar; Spesolimab (INN) research-grade biosimilar; spesolimab-sbzo research-grade biosimilar; Spevigo research-grade biosimilar ;IL1RL2 antibody; IL1RRP2 antibody; Interleukin-1 receptor-like 2 antibody; EC 3.2.2.6 antibody; IL-36 receptor antibody; IL-36R antibody; Interleukin-1 receptor-related protein 2 antibody; IL-1Rrp2 antibody; IL1R-rp2 antibody

Species Reactivity

Human

Immunogen

Recombinant Human IL1RL2 protein

Conjugate

Non-conjugated

Clonality

Monoclonal

Buffer

0.01M PBS，pH7.4

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Notes

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Lead Time

3-4 weeks
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Concentration

It differs from different batches. Please contact us to confirm it.

Usage

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Datasheet & COA

Antibody FAQs

Description

This recombinant monoclonal antibody is developed as a research-grade biosimilar to Spesolimab, targeting IL1RL2 (Interleukin-1 Receptor-Like 2), also known as IL-36R. IL1RL2 serves as the receptor for IL-36 cytokines, which are members of the interleukin-1 superfamily that play critical roles in innate immune responses and inflammatory signaling. Upon ligand binding, IL1RL2 activates downstream pathways including NF-κB and MAPK, leading to the production of pro-inflammatory mediators. Dysregulated IL-36/IL1RL2 signaling has been implicated in various autoinflammatory and autoimmune conditions, particularly generalized pustular psoriasis (GPP), palmoplantar pustulosis, and other neutrophilic dermatoses.

Spesolimab is a humanized IgG1 monoclonal antibody that selectively blocks IL1RL2, preventing IL-36 cytokine binding and subsequent inflammatory cascade activation. This biosimilar antibody provides researchers with a valuable tool for investigating IL-36 receptor biology, studying inflammatory disease mechanisms, and exploring therapeutic interventions in IL-36-driven pathological conditions. It enables detailed examination of IL1RL2-mediated signaling pathways and immune cell activation in various experimental models.

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Target Background

Function(From Uniprot)

Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.

Gene References into Functions

Endothelial cells, including dermal microvascular cells, express a functionally active IL-36 receptor. PMID:27673278
All human blood lymphocytes express IL-36R. PMID:27269181
The data identify a novel role for IL-36 signaling in colonic inflammation and indicate that the IL-36R pathway may represent a novel target for therapeutic intervention. PMID:26813344
single nucleotide polymorphism A471T in the Toll-interleukin 1 receptor domain (TIR) of the IL-1Rrp2 that is present in approximately 2% of the human population, down-regulated IL-36R signaling by a decrease of interaction with IL-1RAcP. PMID:27307043
The IL36 receptor (IL1RL2) is an important mediator molecule in the inflammatory response. PMID:27853811
The ubiquitin-binding Tollip protein contributed to IL-36R signaling and increased the accumulation of both subunits of the IL-36R. PMID:26269592
IL36A-IL36R axis is modulated in patients with primary Sjogren's syndrome. PMID:25902739
Expression of IL-1Rrp2 by sone dendritic cell subsets may have an important function in the human immune response in vivo via its role in differentiation of inflammatory Th1 lymphocytes. PMID:22144259
These data provide evidence that IL-38 binds to the IL-36R, as does IL-36Ra.[IL-38, IL-36R] PMID:22315422
IL-1alpha and IL-1beta gene polymorphisms do not act as a strong susceptibility factor for MTLE-HS in individuals of Turkish ancestry PMID:16546408

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Interleukin-1 receptor family

Tissue Specificity

Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte-derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level.

Database Links

HGNC: 5999

UNIGENE: Hs.659863

KEGG: hsa:8808

STRING: 9606.ENSP00000264257

OMIM: 604512

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