Abbreviation
Recombinant Human IL1RL2 protein, partial (Active)
Purity
Greater than 95% as determined by SDS-PAGE.
Endotoxin
Less than 1.0 EU/ug as determined by LAL method.
Activity
①Measured by its binding ability in a functional ELISA. Immobilized Human IL1RL2 at 2 μg/mL can bind Anti-IL1RL2 recombinant antibody (CSB-RA888016MA1HU). The EC50 is 23.85-32.68 ng/mL.
②IL1RL2 Recombinant Monoclonal Antibody (CSB-RA888016MA1HU) captured on Protein A Chip can bind Human IL1RL2 with an affinity constant of 0.513 nM as detected by MetaSPR Assay (WeSPRTM 200).
Alternative Names
Interleukin-1 receptor-like 2; EC 3.2.2.6; IL-36 receptor; IL-36R; Interleukin-1 receptor-related protein 2; IL-1Rrp2; IL1R-rp2
Species
Homo sapiens (Human)
Expression Region
20-335aa
Target Protein Sequence
DGCKDIFMKNEILSASQPFAFNCTFPPITSGEVSVTWYKNSSKIPVSKIIQSRIHQDETWILFLPMEWGDSGVYQCVIKGRDSCHRIHVNLTVFEKHWCDTSIGGLPNLSDEYKQILHLGKDDSLTCHLHFPKSCVLGPIKWYKDCNEIKGERFTVLETRLLVSNVSAEDRGNYACQAILTHSGKQYEVLNGITVSITERAGYGGSVPKIIYPKNHSIEVQLGTTLIVDCNVTDTKDNTNLRCWRVNNTLVDDYYDESKRIREGVETHVSFREHNLYTVNITFLEVKMEDYGLPFMCHAGVSTAYIILQLPAPDFR
Note: The complete
sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is
translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application,
please explicitly request the full and complete sequence of this protein before ordering.
Tag Info
C-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Buffer
Lyophilized from a 0.2 μm sterile filtered PBS, 6% Trehalose, pH 7.4
Storage
Store at -20°C/-81°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Lead Time
Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Shelf Life
The shelf life is related to many factors, storage state, storage temperature and the stability of the product itself. Generally, the shelf life of lyophilized form is 6 months at -20°C/-80°C from the date of receipt.
Datasheet & COA
Please contact us to get it.
Images
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(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Activity
Measured by its binding ability in a functional ELISA. Immobilized Human IL1RL2 at 2 μg/ml can bind Anti-IL1RL2 recombinant antibody (CSB-RA888016MA1HU). The EC50 is 23.85-32.68 ng/mL.
-
Activity
IL1RL2 Recombinant Monoclonal Antibody (CSB-RA888016MA1HU) captured on Protein A Chip can bind Human IL1RL2 with an affinity constant of 0.513 nM as detected by MetaSPR Assay (WeSPRTM 200).
Description
IL-36 receptor signaling plays a central role in innate immune responses and inflammatory disease pathways, making IL1RL2 a target of interest for therapeutic antibody development and cytokine biology studies. This mammalian-expressed extracellular domain (aa 20–335) exhibits a binding affinity of 0.513 nM to a recombinant anti-IL1RL2 antibody as measured by surface plasmon resonance, demonstrating the conformational integrity required for ligand-receptor interaction assays and epitope mapping experiments. The protein supports therapeutic antibody screening and validation workflows, with functional ELISA data showing an EC50 of 23.85–32.68 ng/mL when immobilized at 2 μg/mL, providing quantitative benchmarks for competitive inhibition studies and blocking antibody characterization. Endotoxin levels below 1.0 EU/μg and purity exceeding 95% align with standards expected in SPR-based affinity measurements and antibody discovery campaigns where low background interference is essential.
