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C1S (Claseprubart Biosimilar) Recombinant Monoclonal Antibody

C1S (Claseprubart Biosimilar) Recombinant Monoclonal Antibody

Code: CSB-RA003657MB2HU

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Size:

100ug

100ug500ug1mg5mg10mg50mg100mg200mg

US$199

Quantity:

Species Reactivity: Human

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Target Background

Product Details

Uniprot NO.

P09871

Target Names

C1S

Alternative Names

DNTH103 research-grade biosimilar; DNTH 103 research-grade biosimilar; DNTH-103 research-grade biosimilar; TX301 research-grade biosimilar; ZB-005 research-grade biosimilar ;C1S antibody; Complement C1s subcomponent antibody; EC 3.4.21.42 antibody; C1 esterase antibody; Complement component 1 subcomponent s [Cleaved into: Complement C1s subcomponent heavy chain antibody; Complement C1s subcomponent chain A antibody; Complement C1s subcomponent light chain antibody; Complement C1s subcomponent chain B] antibody

Species Reactivity

Human

Immunogen

Recombinant Human C1S protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

0.01M PBS，pH7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Notes

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Lead Time

3-4 weeks
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Datasheet & COA

Antibody FAQs

Description

This recombinant monoclonal antibody is a research-grade biosimilar to Claseprubart, designed for research applications targeting complement component 1s (C1S). C1S is a serine protease that functions as part of the C1 complex in the classical complement pathway, where it cleaves complement components C2 and C4 to initiate the complement cascade. This proteolytic activity plays a critical role in immune defense, but dysregulated C1S activation contributes to various pathological conditions including autoimmune diseases, antibody-mediated rejection in transplantation, and complement-mediated inflammatory disorders. Aberrant complement activation has been implicated in conditions such as cold agglutinin disease and other complement-driven hemolytic anemias.

Claseprubart is a therapeutic antibody developed to selectively inhibit C1S activity, thereby modulating classical complement pathway activation. This biosimilar provides researchers with a valuable tool for investigating C1S-mediated mechanisms in complement biology, exploring the role of classical pathway activation in disease models, and evaluating potential therapeutic strategies for complement-related disorders. It enables detailed studies of complement regulation and immune-mediated pathologies in controlled laboratory settings.

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Target Background

Function(From Uniprot)

C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.

Gene References into Functions

TNT003, an inhibitor of the serine protease C1s, prevents complement activation induced by cold agglutinins. PMID:24695853
Data indicate that complement C1s mRNA level was low in ICR-derived glomerulonephritis (ICGN) mice liver as compared with age-matched ICR mice. PMID:23989031
A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4. PMID:23592783
Four positively charged amino acids on the serine protease domain appear to form a catalytic exosite that is required for efficient cleavage of C4 in the classical pathway of complement. PMID:22855709
Detailed mapping of post-translational modifications and insights into the C1r/C1s binding sites. PMID:20008834
Interaction with the prime side residues at the cleavage point in C1s enhances the affinity of the enzyme for complement 2 and complement 4 substrates; these prime subsite residues mediate positive cooperativity in the cleavage of the substrate. PMID:14674770
full specificity of the enzyme using a randomized phage display library PMID:16169853
There are splice variants of C1s mRNA transcripts in normal human cells PMID:18062908