Abbreviation
Recombinant Human TNFRSF13C protein, partial (Active)
Purity
>95% as determined by SDS-PAGE.
Endotoxin
Less than 1.0 EU/μg as determined by LAL method.
Activity
Fully biologically active when compared to standard. The ED50 as determined by its ability to block BAFF induced mouse splenocyte survival is 1.0-5.0 ug/ml in the presence of 1.0 μg/ml of rHuBAFF.
Alternative Names
B cell activating factor receptor; B-cell-activating factor receptor; BAFF R; BAFF receptor; BAFF-R; BAFFR; BLyS receptor 3; BlySR3; BR 3; BR3; BROMIX; CD 268; CD268; CD268 antigen; CVID4; MGC138235; OTTHUMP00000028746; Prolixin; TNFRSF 13C; Tnfrsf13c; TR13C_HUMAN; Tumor necrosis factor receptor subunit member 13C; Tumor necrosis factor receptor superfamily member 13C
Species
Homo sapiens (Human)
Target Protein Sequence
MRRGPRSLRG RDAPAPTPCV PAECFDLLVR HCVACGLLRT PRPKPAGASS PAPRTALQPQ ESVGAGAGEA ALPLPG
Note: The complete
sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is
translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application,
please explicitly request the full and complete sequence of this protein before ordering.
Tag Info
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Buffer
Lyophilized from a 0.2 µm filtered 20 mM PB, pH 8.0, 500 mM NaCl
Lead Time
5-10 business days
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Datasheet & COA
Please contact us to get it.
Description
BAFF-R (TNFRSF13C) serves as the primary receptor driving BAFF-dependent B cell survival, making it a critical target in autoimmune disease and B cell malignancy research. This tag-free recombinant construct spans the extracellular ligand-binding domain (residues 1–76) and demonstrates confirmed blocking activity, with an ED50 of 1.0–5.0 µg/ml for inhibiting BAFF-induced mouse splenocyte survival in the presence of 1.0 µg/ml recombinant human BAFF. This functional validation supports use in competitive inhibition assays, blocking antibody screening, BAFF–BAFF-R interaction studies by SPR or BLI, and small-molecule inhibitor discovery campaigns targeting the BAFF signaling axis. Expressed in *E. coli* without affinity tags, the protein provides a suitable basis for epitope mapping and ligand-binding ELISAs, with purity exceeding 95% by SDS-PAGE and endotoxin levels below 1.0 EU/µg—criteria that satisfy requirements for cell-based functional assays.
