Recombinant Rat IgG receptor FcRn large subunit p51 (Fcgrt)

1. significant structural changes occur to albumin with glycation, particularly in the FcRn-binding region, which could explain the reduced affinity to FcRn PMID:26887834
2. The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity. PMID:25658443
3. Characterization and screening of IgG binding to the neonatal Fc receptor. PMID:24802048
4. Fetal transfer of Avastins mutated in the portion of the antibody that binds the neonatal Fc receptor (FcRn) was tested in late gestation and was found to correlate with affinities of the mutant Avastin antibody to FcRn. PMID:22969064
5. The suckling rat pup intestine is a mechanistic model of FcRn-IgG-mediated transcytosis PMID:23220220
6. multivesicular bodies function in IgG transport while FcRn is expressed but switch to degradative functions after weaning, when the jejunum does not express FcRn or transport IgG. PMID:22573886
7. IgG transport across alveolar epithelium takes place via regulable FcRn-mediated transcytosis, which may play an important role in alveolar homeostasis in health and disease. PMID:15169676
8. interactions between the tryptophan-based endocytosis signal, WLSL, contained within the cytoplasmic domain of the neonatal Fc receptor and the mu2 subunit of AP-2 PMID:15598658
9. pulmonary epithelium expresses functional FcRn providing an absorption pathway potentially important for highly potent Fcgamma-fusion proteins PMID:16382279
10. results present a complex picture in which Fc moves through networks of entangled tubular and irregular vesicles, only some of which are microtubule-associated, as it migrates to the basolateral surface PMID:18818657
11. N-glycans in FcRn contribute significantly to the steady-state membrane distribution and direction of IgG transport in polarized epithelia. PMID:19164298

Show More

Hide All

UNIGENE: Rn.15845

KEGG: rno:29558

STRING: 10116.ENSRNOP00000027944