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Recombinant Rat IgG receptor FcRn large subunit p51 (Fcgrt), partial

Recombinant Rat IgG receptor FcRn large subunit p51 (Fcgrt), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Fcgrt

Uniprot NO.

P13599

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

23-298

Target Protein Sequence

AEPRLPLM YHLAAVSDLS TGLPSFWATG WLGAQQYLTY NNLRQEADPC GAWIWENQVS WYWEKETTDL KSKEQLFLEA IRTLENQING TFTLQGLLGC ELAPDNSSLP TAVFALNGEE FMRFNPRTGN WSGEWPETDI VGNLWMKQPE AARKESEFLL TSCPERLLGH LERGRQNLEW KEPPSMRLKA RPGNSGSSVL TCAAFSFYPP ELKFRFLRNG LASGSGNCST GPNGDGSFHA WSLLEVKRGD EHHYQCQVEH EGLAQPLTVD LDSPARSS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Extracellular domain

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB.

Gene References into Functions

significant structural changes occur to albumin with glycation, particularly in the FcRn-binding region, which could explain the reduced affinity to FcRn PMID:26887834
The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity. PMID:25658443
Characterization and screening of IgG binding to the neonatal Fc receptor. PMID:24802048
Fetal transfer of Avastins mutated in the portion of the antibody that binds the neonatal Fc receptor (FcRn) was tested in late gestation and was found to correlate with affinities of the mutant Avastin antibody to FcRn. PMID:22969064
The suckling rat pup intestine is a mechanistic model of FcRn-IgG-mediated transcytosis PMID:23220220
multivesicular bodies function in IgG transport while FcRn is expressed but switch to degradative functions after weaning, when the jejunum does not express FcRn or transport IgG. PMID:22573886
IgG transport across alveolar epithelium takes place via regulable FcRn-mediated transcytosis, which may play an important role in alveolar homeostasis in health and disease. PMID:15169676
interactions between the tryptophan-based endocytosis signal, WLSL, contained within the cytoplasmic domain of the neonatal Fc receptor and the mu2 subunit of AP-2 PMID:15598658
pulmonary epithelium expresses functional FcRn providing an absorption pathway potentially important for highly potent Fcgamma-fusion proteins PMID:16382279
results present a complex picture in which Fc moves through networks of entangled tubular and irregular vesicles, only some of which are microtubule-associated, as it migrates to the basolateral surface PMID:18818657
N-glycans in FcRn contribute significantly to the steady-state membrane distribution and direction of IgG transport in polarized epithelia. PMID:19164298