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Recombinant Rat Glutamate carboxypeptidase 2 (Folh1)

Recombinant Rat Glutamate carboxypeptidase 2 (Folh1)

CSB-CF008782RA

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20μg100μg

US$8122

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Express system: in vitro E.coli expression system

Species: Rattus norvegicus (Rat)

Tag Info: N-terminal 10xHis-tagged

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Target Background

Product Details

Target Names

Folh1

Uniprot NO.

P70627

Species

Rattus norvegicus (Rat)

Source

in vitro E.coli expression system

Expression Region

1-752

Target Protein Sequence

MWNAQQDSDSAEALGRRQRWFCAGTLVLAFTGTFIIGFLFGWFIKPSNDSTSSVSYPGMKKAFLQELKAENIKKFLYNFTRTPHLAGTQHNFELAKQIHAQWKEFGLDLVELSDYDVLLSYPNKTHPNYISIINEDGNEIFKTSLAELSPPGYENISDVVPPYSAFSPQGTPEGDLVYVNYARTEDFFKLERVMKINCSGKIVIARYGQVFRGNKVKNAQLAGAKGIILYSDPADYFVPGVKSYPDGWNLPGGGVQRGNVLNLNGAGDPLTPGYPANEYAYRHEFTEAVGLPSIPVHPIGYDDAQKLLEHMGGSAPPDSSWKGGLKVPYNVGPGFAGNFSKQKVKLHIHSYNKVTRIYNVIGTLKGAVEPDRYVILGGHRDAWVFGGIDPQSGAAVVHEIVRTFGTLKKKGWRPRRTILFASWDAEEFGLLGSTEWAEEHSRLLQERGVAYINADSSIEGNYTLRVDCTPLMHSLVYNLTKELPSPDEGFEGKSLYDSWKEKSPSTEFIGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNWKNNKVSSYPLYHSVYETYELVEKFYDPTFKYHLTVAQVRGAMVFELANSIVLPFDCQSYAVALKKHAETIYNISMNHPQEMKAYMISFDSLFSAVNNFTDVASKFNQRLQDLDKSNPILLRILNDQLMYLERAFIDPLGLPGRPFYRHIIYAPSSHNKYAGESFPGIYDALFDINNKVDTSKAWREVKRQISIAAFTVQAAAETLREVD

Protein Length

full length protein

Tag Info

N-terminal 10xHis-tagged

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Description

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Target Background

Function

Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate.; Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.

Gene References into Functions

NAAG peptidase inhibition has a role in release of glutamate and dopamine in prefrontal cortex and nucleus accumbens in phencyclidine model of schizophrenia PMID:22570482
role of glutamate carboxypeptidase II inhibition in preventing programmed cell death in neurons exposed to high glucose; this neuroprotection is mediated through the mGluR3 receptor, most likely by increasing the extracellular NAAG concentration PMID:15030392
Tissues such as prostate and testes exhibit different GCPII expression levels among the species studied (human, rats, swine). PMID:18076021

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Subcellular Location

Cell membrane; Single-pass type II membrane protein.

Protein Families

Peptidase M28 family, M28B subfamily

Tissue Specificity

Widely expressed throughout brain regions with highest levels in the hippocampus, dentate gyrus, priform cortex, choroid plexus of ventricles, pineal gland, anterior lobe of the pituitary gland and supraoptic nucleus. High levels also found in the cerebra

Database Links

UNIGENE: Rn.89278

KEGG: rno:85309

STRING: 10116.ENSRNOP00000018592

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