TNFRSF1A; TNFR1; Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor 1; TNF-R1; Tumor necrosis factor receptor type I; TNF-RI; TNFR-I; p55; p60; CD antigen CD120a
Species
Sus scrofa (Pig)
Source
in vitro E.coli expression system
Expression Region
22-461
Target Protein Sequence
VYPAGVHGLVLHPGDREKRESLCPQGKYSHPQNRSICCTKCHKGTYLHNDCLGPGLDTDCRECDNGTFTASENHLTQCLSCSKCRSEMSQVEISPCTVDRDTVCGCRKNQYRKYWSETLFQCLNCSLCPNGTVQLPCLEKQDTICNCHSGFFLRDKECVSCVNCKNADCKNLCPATSETRNDFQDTGTTVLLPLVIFFGLCLAFFLFVGLACRYQRWKPKLYSIICGKSTPVKEGEPEPLATAPSFGPITTFSPIPSFSPTTTFSPVPSFSPISSPTFTPCDWSNIKVTSPPKEIAPPPQGAGPILPMPPASTPVPTPLPKWGGSAHSAHSAPAQLADADPATLYAVVDGVPPTRWKEFVRRLGLSEHEIERLELQNGRCLREAQYSMLAEWRRRTSRREATLELLGSVLRDMDLLGCLEDIEEALRGPARLAPAPHLLR
Note: The complete
sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is
translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application,
please explicitly request the full and complete sequence of this protein before ordering.
Protein Length
Full Length of Mature Protein
Tag Info
N-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Storage Condition
Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
Gene References into Functions
Retinal ischemia results in increased expression of TNF-alpha and its receptors (TNF-R1 and TNF-R2).PMID:21152396
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Subcellular Location
Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein.