Recombinant Mouse T-cell surface glycoprotein CD5 (Cd5)

1. The natural substrate for the cell surface sialidase was identified as clustered differentiation 5 (CD5) by PNA-blot analysis of anti-CD5 immunoprecipitate. PMID:29897583
2. FasL expression in splenic CD5(+)CD1d(hi) B cells was decreased compared to the control group after TLR4 ligation. PMID:28505514
3. CD5-CK2 signaling axis regulates positive selection by modulating activation of ERK and promoting survival independent of proximal TCR signals PMID:28030587
4. the reduction in the positive selection conferred by CD5 overexpression was unaffected by SHP-1 deficiency. PMID:27221212
5. In mice lacking functional KDELR1, surviving naive T cells expressed significantly higher levels of CD5, a surrogate marker of TCR self-reactivity. PMID:26489882
6. In mouse tumor models, CD5(+) but not CD5(-) B cells promoted tumor growth. The results demonstrate a critical role of CD5(+) B cells in promoting cancer. PMID:27096320
7. CD5 and CD72 play a critical role in maintaining regulatory T and B cell homeostasis PMID:24950378
8. CD5 promoted Treg cell induction in response to self and tolerizing antigens by blocking mTOR activation. PMID:25786177
9. Data indicate that CD5-casein kinase 2 (CK2) signaling is necessary for efficient nuclear localization of orphan nuclear receptor ROR-gammaT (RORgammat). PMID:24356888
10. Although the percentage of CD1d(hi)CD5+ subset in splenic B cells does not change significantly, percent IL-10-expressing cells among total splenic B cells or the CD1dhiCD5+ population significantly increases 3-7 days after rCRT/39-272 administration PMID:23523122
11. Different CD5 expression levels influence the proliferation dynamics of activated naive CD4+ T cells while leaving the conversion rate of those cells into memory cells unaffected. PMID:23100516
12. CD5 glycoprotein-mediated T cell inhibition dependent on inhibitory phosphorylation of Fyn kinase PMID:21757751
13. Delayed tumor growth in CD5-deficient mice is associated with enhanced activation of tumor-infiltrating lymphocytes due to an upregulated T cell response to T cell receptor (TCR) stimulation. PMID:21622855
14. A conserved enhancer element differentially regulates developmental expression of CD5 in B and T cells. PMID:21076064
15. Absence of CD5 dramatically reduces progression of pulmonary inflammatory lesions in SHP-1 protein-tyrosine phosphatase-deficient 'viable motheaten' mice. PMID:11908943
16. CD5, an important regulator of lymphocyte selection and immune tolerance. Review. PMID:12403363
17. CD5 is rapidly recruited at the immunological synapse (IS) and lowers the T cell response elicited by antigen presentation by targeting downstream signaling events without affecting IS formation. PMID:12707340
18. The mechanism that mediates this dynamic antigen-specific T cell unresponsiveness differs from previously described forms of tolerance in that it requires that DCs induce CD5 expression on activated T cells PMID:15189735
19. a direct role for CD5-CK2 pathway in T cell activation and persistence of effector T cells in neuroinflammatory disease PMID:17142752
20. Ly-1 antibody reactive Embryonic stem cells functions to control the stability of nucleolin protein, which in turn is essential for maintaining their self-renewal PMID:19489080
21. Data provide new evidence supporting a potential role of CD5 in thymocyte survival, through a mechanism that may involve the phosphorylation of Akt. PMID:19609976
22. Reduced numbers of splenic FasL+ CD5+ B cells correlated with increasing arthritis severity and decreased T-cell death in a T-cell receptor transgenic mouse model of collagen-induced arthritis. PMID:19706160

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UNIGENE: Mm.779

KEGG: mmu:12507

STRING: 10090.ENSMUSP00000025571