Recombinant Mouse Glycophorin-A (Gypa)

CSB-CF010074MO

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20μg100μg

US$3751

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Express system: in vitro E.coli expression system

Species: Mus musculus (Mouse)

Tag Info: N-terminal 10xHis-tagged

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Target Background

Product Details

Target Names

Gypa

Uniprot NO.

P14220

Species

Mus musculus (Mouse)

Source

in vitro E.coli expression system

Expression Region

1-168

Target Protein Sequence

MTESTAAVTTSGHSLTTTFHIPSSQHYQEEHSPSLSGSDSLLQITTPVVASTVGNPNQHSATMSTPAIHVSTYHTAPTEVSAAFEEQPVSPHIGGMPSPIQHDFPALVMILIILGVMAGIIGTILLISYCISRMTKKSSVDIQSPEGGDNSVPLSSIEQTPNEESSNV

Protein Length

full length protein

Tag Info

N-terminal 10xHis-tagged

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Description

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Target Background

Function

Glycophorin A is the major intrinsic membrane sialoglycoprotein of the erythrocyte. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane.

Gene References into Functions

Data suggest that glycophorin A (Gpa) increases expression and activity of Cl-/HCO3- exchanger Ae1, that G719D mutation renders Ae1 mutant constructs GPA-unresponsive, and suggests a role for Ae1 amino acids 22-28 in GPA responsiveness. PMID:21455273
Glycophorin A has an essential role in the expression of O-linked antigens on the erythrocyte membrane. PMID:12940824
SCL is a nucleation factor within a higher-order complex required to activate glycophorin A expression PMID:14749362
The resistance of glycophorin A knockout mice against infection with the OB1 variant of Babesia rohaini may be attributed to the effective clearance of the parasitized erythrocytes lacking GPA in the spleen. PMID:19084340