Recombinant Mouse B-cell differentiation antigen CD72 (Cd72)

1. CD72 appears to specifically inhibit B cell response to the endogenous TLR7 ligand Sm/RNP. PMID:27810925
2. CD72 negatively regulates mouse mast cell functions and down-regulates the expression of KIT and FcepsilonRIalpha. PMID:25239131
3. These results strongly suggest that the Cd72(c) is a crucial modifier gene that regulates Fas(lpr)-induced autoimmune disease due to its reduced activity of B cell signal regulation. PMID:23616572
4. Cd72 polymorphism affects susceptibility to lupus phenotypes. PMID:23365086
5. Inhibitory coreceptors CD72 and CD22 are responsible for setting the requirement of CD40 signaling for survival and proliferation of antigen-stimulated spleen B cells. PMID:12902484
6. results strongly suggest that the apoptosis preventing signal evoked by CD72 ligation is delivered through the pathway of NF-kappaB, c-Myc, p27(Kip1) and cyclin PMID:14734859
7. Strength of B-cell antigen receptor signals is strictly tuned by the interaction of CD100 with CD72; this interaction is essential for maintaining immunological homeostasis as well as generating a proper immune response. PMID:16113236
8. CD72 plays a dominant role as a negative regulator of BCR signaling in primary mature B lymphocytes. PMID:16621999
9. CD72 is required to maintain B cell anergy and functions as a regulator of peripheral B cell tolerance PMID:18821699
10. CD72 is an inhibitory receptor on NK cells regulating cytokine production. PMID:19197938
11. CD72 activates extracellular signal-regulated kinase and c-Jun N-terminal kinase (but not p38 mitogen-activated protein kinase), synergizing with B cell receptor signals to induce proliferation of B cells in X-linked immunodeficiency. PMID:11466342

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UNIGENE: Mm.188157

KEGG: mmu:12517

STRING: 10090.ENSMUSP00000030179